NAT10

Protein-coding gene in the species Homo sapiens

NAT10

Identifiers

Aliases

NAT10, ALP, NET43, N-acetyltransferase 10, Kre33

External IDs

OMIM: 609221; MGI: 2138939; HomoloGene: 6785; GeneCards: NAT10; OMA:NAT10 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11p13	Start	34,105,617 bp^[1]
Band	11p13	End	34,147,670 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 E2	Start	103,551,601 bp^[2]
Band	2\|2 E2	End	103,591,615 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

skin of leg

skin of abdomen

ventricular zone

right ovary

left ovary

Achilles tendon

body of pancreas

tonsil

right uterine tube

Top expressed in

spermatocyte

epiblast

neural layer of retina

yolk sac

primitive streak

spermatid

tail of embryo

Paneth cell

lens

ventricular zone

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding acyltransferase activity protein binding ATP binding N-acetyltransferase activity tRNA binding tRNA N-acetyltransferase activity rRNA cytidine N-acetyltransferase activity RNA binding DNA polymerase binding
Cellular component	nucleolus membrane nucleus telomerase holoenzyme complex nucleoplasm midbody 90S preribosome
Biological process	rRNA processing negative regulation of telomere maintenance via telomerase tRNA processing ncRNA processing rRNA metabolic process rRNA modification tRNA wobble cytosine modification tRNA acetylation rRNA acetylation involved in maturation of SSU-rRNA ribosomal small subunit biogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55226


98956

Ensembl


ENSG00000135372


ENSMUSG00000027185

UniProt


Q9H0A0


Q8K224

RefSeq (mRNA)


NM_001144030 NM_024662


NM_153126

RefSeq (protein)


NP_001137502 NP_078938


NP_694766

Location (UCSC)

Chr 11: 34.11 – 34.15 Mb

Chr 2: 103.55 – 103.59 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

N-acetyltransferase 10 is an enzyme that in humans is encoded by the NAT10 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135372 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027185 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lv J, Liu H, Wang Q, Tang Z, Hou L, Zhang B (Nov 2003). "Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT". Biochemical and Biophysical Research Communications. 311 (2): 506–13. doi:10.1016/j.bbrc.2003.09.235. PMID 14592445.
^ "Entrez Gene: NAT10 N-acetyltransferase 10".

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Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Chi YH, Haller K, Peloponese JM, Jeang KT (Sep 2007). "Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes" (PDF). The Journal of Biological Chemistry. 282 (37): 27447–58. doi:10.1074/jbc.M703098200. PMID 17631499. S2CID 44621298.