NDST1

Enzyme
NDST1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1NST

Identifiers
AliasesNDST1, HSST, NST1, MRT46, N-deacetylase/N-sulfotransferase 1, N-deacetylase and N-sulfotransferase 1
External IDsOMIM: 600853; MGI: 104719; HomoloGene: 20386; GeneCards: NDST1; OMA:NDST1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for NDST1
Genomic location for NDST1
Band5q33.1Start150,485,818 bp[1]
End150,558,211 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for NDST1
Genomic location for NDST1
Band18|18 E1Start60,817,566 bp[2]
End60,881,722 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • C1 segment

  • olfactory bulb

  • subthalamic nucleus

  • inferior ganglion of vagus nerve

  • right lobe of liver

  • lateral nuclear group of thalamus

  • mucosa of esophagus

  • inferior olivary nucleus

  • upper lobe of left lung
Top expressed in
  • right lung lobe

  • left lung

  • left lung lobe

  • lacrimal gland

  • epithelium of stomach

  • left lobe of liver

  • human fetus

  • salivary gland

  • vas deferens

  • digastric muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • deacetylase activity
  • catalytic activity
  • hydrolase activity
  • N-acetylglucosamine deacetylase activity
  • protein binding
  • [heparan sulfate-glucosamine N-sulfotransferase activity]
  • heparan sulfate N-acetylglucosaminyltransferase activity
  • heparan sulfate sulfotransferase activity
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • membrane
  • Golgi membrane
Biological process
  • cardiac septum development
  • heparin biosynthetic process
  • embryonic neurocranium morphogenesis
  • coronary vasculature development
  • respiratory gaseous exchange by respiratory system
  • fibroblast growth factor receptor signaling pathway
  • aorta development
  • heart development
  • glycosaminoglycan biosynthetic process
  • animal organ morphogenesis
  • embryonic viscerocranium morphogenesis
  • polysaccharide biosynthetic process
  • forebrain development
  • metabolism
  • protein sulfation
  • inflammatory response
  • midbrain development
  • glycosaminoglycan metabolic process
  • heparan sulfate proteoglycan biosynthetic process
  • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
  • positive regulation of MAPK cascade
  • positive regulation of smoothened signaling pathway
  • sulfur compound metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3340

15531

Ensembl

ENSG00000070614

ENSMUSG00000054008

UniProt

P52848

Q3UHN9

RefSeq (mRNA)

NM_001301063
NM_001543

NM_008306
NM_001348100
NM_001348101
NM_001348102
NM_001348103

NM_001348146

RefSeq (protein)

NP_001287992
NP_001534

NP_032332
NP_001335029
NP_001335030
NP_001335031
NP_001335032

NP_001335075

Location (UCSC)Chr 5: 150.49 – 150.56 MbChr 18: 60.82 – 60.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070614 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054008 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ (Aug 1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1". Genomics. 26 (2): 239–44. doi:10.1016/0888-7543(95)80206-2. PMID 7601448.
  6. ^ Humphries DE, Sullivan BM, Aleixo MD, Stow JL (Aug 1997). "Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network". Biochem J. 325. ( Pt 2) (2): 351–7. doi:10.1042/bj3250351. PMC 1218567. PMID 9230113.
  7. ^ "Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1".

Further reading

  • Sueyoshi T, Kakuta Y, Pedersen LC, et al. (1998). "A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase". FEBS Lett. 433 (3): 211–4. doi:10.1016/S0014-5793(98)00913-2. PMID 9744796. S2CID 9055616.
  • Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J. Biol. Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
  • Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC (1999). "Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1". J. Biol. Chem. 274 (16): 10673–6. doi:10.1074/jbc.274.16.10673. PMID 10196134.
  • Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns". Biochemistry. 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005.
  • Mura CV, Becker MI, Orellana A, Wolff D (2002). "Immunopurification of Golgi vesicles by magnetic sorting". J. Immunol. Methods. 260 (1–2): 263–71. doi:10.1016/S0022-1759(01)00546-4. PMID 11792394.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bengtsson J, Eriksson I, Kjellén L (2003). "Distinct effects on heparan sulfate structure by different active site mutations in NDST-1". Biochemistry. 42 (7): 2110–5. doi:10.1021/bi026928g. PMID 12590599.
  • van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2". Glycobiology. 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318.
  • Nakayama K, Natori Y, Sato T, et al. (2004). "Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis". J. Lab. Clin. Med. 143 (2): 106–14. doi:10.1016/j.lab.2003.10.012. PMID 14966466.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • v
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  • 1nst: THE SULFOTRANSFERASE DOMAIN OF HUMAN HAPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE
    1nst: THE SULFOTRANSFERASE DOMAIN OF HUMAN HAPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE


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