NDST3

Enzyme
NDST3
Identifiers
AliasesNDST3, HSST3, N-deacetylase/N-sulfotransferase 3, N-deacetylase and N-sulfotransferase 3
External IDsOMIM: 603950; MGI: 1932544; HomoloGene: 3513; GeneCards: NDST3; OMA:NDST3 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NDST3
Genomic location for NDST3
Band4q26Start118,033,618 bp[1]
End118,258,634 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for NDST3
Genomic location for NDST3
Band3|3 G1Start123,319,815 bp[2]
End123,484,502 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • cerebellar cortex

  • cerebellar hemisphere

  • testicle

  • right hemisphere of cerebellum

  • prefrontal cortex

  • ganglionic eminence

  • nucleus accumbens

  • Brodmann area 9

  • right frontal lobe
Top expressed in
  • cerebellar cortex

  • spermatid

  • primary visual cortex

  • seminiferous tubule

  • superior frontal gyrus

  • lumbar subsegment of spinal cord

  • neural layer of retina

  • inferior colliculus

  • dentate gyrus of hippocampal formation granule cell

  • cerebellar vermis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • catalytic activity
  • hydrolase activity
  • [heparan sulfate-glucosamine N-sulfotransferase activity]
  • heparan sulfate N-acetylglucosaminyltransferase activity
  • deacetylase activity
  • heparan sulfate sulfotransferase activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • Golgi apparatus
  • membrane
  • cellular component
Biological process
  • metabolism
  • heparin biosynthetic process
  • heparan sulfate proteoglycan biosynthetic process
  • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
  • glycosaminoglycan biosynthetic process
  • sulfur compound metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9348

83398

Ensembl

ENSG00000164100

ENSMUSG00000027977

UniProt

O95803

Q9EQH7

RefSeq (mRNA)

NM_004784

NM_001293682
NM_031186

RefSeq (protein)

NP_004775

NP_001280611
NP_112463

Location (UCSC)Chr 4: 118.03 – 118.26 MbChr 3: 123.32 – 123.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene.[5][6] It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H+ + N-sulfo-α-D-glucosaminyl-[heparan sulfate](n)[7]

This is a step in the production of heparin.[7]

Clinical significance

Mutations in NDST3 have been linked to schizophrenia.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164100 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027977 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J Biol Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
  6. ^ "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".
  7. ^ a b "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". www.uniprot.org. Retrieved 2020-01-15.
  8. ^ Zhang, C; Lu, W; Wang, Z; Ni, J; Zhang, J; Tang, W; Fang, Y (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese". Translational Psychiatry. 6 (1): e701. doi:10.1038/tp.2015.199. ISSN 2158-3188. PMC 5068873. PMID 26731438.

Further reading

  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Aikawa J, Grobe K, Tsujimoto M, Esko JD (2001). "Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4". J. Biol. Chem. 276 (8): 5876–82. doi:10.1074/jbc.M009606200. PMID 11087757.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Boutry M, Vassarotti A, Ghislain M, et al. (1984). "Isolation of the structural genes for the alpha and beta subunits of the mitochondrial ATPase from the fission yeast Schizosaccharomyces pombe". J. Biol. Chem. 259 (5): 2840–4. doi:10.1016/S0021-9258(17)43223-6. PMID 6230352.


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