NUFIP1

Protein-coding gene in the species Homo sapiens

NUFIP1
Identifiers
AliasesNUFIP1, NUFIP, bA540M5.1, FMR1 interacting protein 1, nuclear FMR1 interacting protein 1, Rsa1
External IDsOMIM: 604354; MGI: 1351474; HomoloGene: 8216; GeneCards: NUFIP1; OMA:NUFIP1 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for NUFIP1
Genomic location for NUFIP1
Band13q14.12Start44,939,249 bp[1]
End44,989,471 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for NUFIP1
Genomic location for NUFIP1
Band14|14 D3Start76,348,331 bp[2]
End76,374,819 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • gonad

  • secondary oocyte

  • ventricular zone

  • testicle

  • ganglionic eminence

  • Brodmann area 23

  • gastrocnemius muscle

  • Achilles tendon

  • islet of Langerhans
Top expressed in
  • primitive streak

  • epiblast

  • renal corpuscle

  • medullary collecting duct

  • external carotid artery

  • Gonadal ridge

  • internal carotid artery

  • Paneth cell

  • abdominal wall

  • endothelial cell of lymphatic vessel
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ATPase binding
  • identical protein binding
  • protein-macromolecule adaptor activity
  • snoRNA binding
  • RNA binding
  • metal ion binding
  • DNA binding
  • nucleic acid binding
Cellular component
  • nuclear matrix
  • nucleus
  • pre-snoRNP complex
  • perichromatin fibrils
  • nucleolus
  • cytosolic ribosome
  • transcription elongation factor complex
  • fibrillar center
  • presynaptic active zone
  • protein-containing complex
  • synapse
Biological process
  • box C/D snoRNP assembly
  • positive regulation of transcription by RNA polymerase II
  • RNA processing
  • protein complex oligomerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26747

27275

Ensembl

ENSG00000083635

ENSMUSG00000022009

UniProt

Q9UHK0

Q9QXX8

RefSeq (mRNA)

NM_012345

NM_013745

RefSeq (protein)

NP_036477

NP_038773

Location (UCSC)Chr 13: 44.94 – 44.99 MbChr 14: 76.35 – 76.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear fragile X mental retardation-interacting protein 1 is a protein that in humans is encoded by the NUFIP1 gene.[5][6][7]

Interactions

NUFIP1 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000083635 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022009 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Bardoni B, Schenck A, Mandel JL (Jan 2000). "A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein". Hum Mol Genet. 8 (13): 2557–66. doi:10.1093/hmg/8.13.2557. PMID 10556305.
  6. ^ Bardoni B, Giglio S, Schenck A, Rocchi M, Mandel JL (Aug 2000). "Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to chromosome 13q14 and assignment of a pseudogene to chromosome 6q12". Cytogenet Cell Genet. 89 (1–2): 11–3. doi:10.1159/000015580. PMID 10894927. S2CID 38381172.
  7. ^ "Entrez Gene: NUFIP1 nuclear fragile X mental retardation protein interacting protein 1".
  8. ^ a b Cabart P, Chew HK, Murphy S (Jul 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825. S2CID 1338899.
  9. ^ Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL (Jul 2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692.

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Cabart P, Chew HK, Murphy S (2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825. S2CID 1338899.
  • Bardoni B, Willemsen R, Weiler IJ, Schenck A, Severijnen LA, Hindelang C, Lalli E, Mandel JL (2003). "NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes". Exp. Cell Res. 289 (1): 95–107. doi:10.1016/S0014-4827(03)00222-2. PMID 12941608.
  • Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL (2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692.


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