Protein-coding gene in the species Homo sapiens
| OR4F5 |
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| Identifiers |
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| Aliases | OR4F5, olfactory receptor family 4 subfamily F member 5 |
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| External IDs | MGI: 3031123; HomoloGene: 128250; GeneCards: OR4F5; OMA:OR4F5 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1p36.33 | Start | 65,419 bp[1] |
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| End | 71,585 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 2 (mouse)[2] |
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| | Band | 2|2 E3 | Start | 111,311,164 bp[2] |
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| End | 111,314,960 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| | | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- transmembrane signaling receptor activity
- signal transducer activity
| | Cellular component | - integral component of membrane
- plasma membrane
- membrane
| | Biological process | - sensory perception of smell
- detection of chemical stimulus involved in sensory perception of smell
- detection of chemical stimulus involved in sensory perception
- signal transduction
- response to stimulus
- G protein-coupled receptor signaling pathway
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 1: 0.07 – 0.07 Mb | Chr 2: 111.31 – 111.31 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Olfactory receptor family 4 subfamily F member 5 is a protein that in humans is encoded by the OR4F5 gene. [5]
Function
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
Trivia
OR4F5 is the first protein coding gene on human chromosome 1.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186092 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061195 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Olfactory receptor family 4 subfamily F member 5".
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
