Protein-coding gene in the species Homo sapiens
OTUD1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | OTUD1, DUBA7, OTDC1, OTU deubiquitinase 1 |
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External IDs | OMIM: 612022; MGI: 1918448; HomoloGene: 45953; GeneCards: OTUD1; OMA:OTUD1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 10 (human)[1] |
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| Band | 10p12.2 | Start | 23,439,075 bp[1] |
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End | 23,442,377 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 A3 | Start | 19,662,563 bp[2] |
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End | 19,665,394 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - buccal mucosa cell
- Skeletal muscle tissue of rectus abdominis
- myocardium of left ventricle
- cardiac muscle tissue of right atrium
- skin of arm
- tibialis anterior muscle
- amniotic fluid
- muscle of thigh
- skin of thigh
- vena cava
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| Top expressed in | - ascending aorta
- aortic valve
- soleus muscle
- tibialis anterior muscle
- quadriceps femoris muscle
- thoracic diaphragm
- muscle of thigh
- secondary oocyte
- digastric muscle
- ankle
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| More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 10: 23.44 – 23.44 Mb | Chr 2: 19.66 – 19.67 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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OTU deubiquitinase 1 is a protein that in humans is encoded by the OTUD1 gene. [5]
Function
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165312 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043415 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: OTU deubiquitinase 1". Retrieved 2016-03-13.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human OTU domain-containing protein 1
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.