Oxyclozanide

Oxyclozanide
Names
Preferred IUPAC name
2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide
Identifiers
CAS Number
  • 2277-92-1 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 15904 ☒N
ECHA InfoCard 100.017.186 Edit this at Wikidata
KEGG
  • D08320 checkY
PubChem CID
  • 16779
UNII
  • 1QS9G4876X checkY
CompTox Dashboard (EPA)
  • DTXSID50177312 Edit this at Wikidata
InChI
  • InChI=1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22) ☒N
    Key: JYWIYHUXVMAGLG-UHFFFAOYSA-N ☒N
  • InChI=1/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)
    Key: JYWIYHUXVMAGLG-UHFFFAOYAW
  • C1=C(C=C(C(=C1Cl)O)NC(=O)C2=C(C(=CC(=C2Cl)Cl)Cl)O)Cl
Properties
Chemical formula
 C13H6Cl5NO3
Molar mass 401.45 g·mol−1
Pharmacology
QP52AG06 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes.[1] Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)".[2]

Sometimes alluded to as "Pentaclosamide": CN101891646.

References

[3]

  1. ^ CID 16779 from PubChem
  2. ^ Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Conery, Annie L.; Kim, Wooseong; Jayamani, Elamparithi; Kwon, Bumsup; Ausubel, Frederick M.; Mylonakis, Eleftherios (2015). "Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus". PLOS ONE. 10 (4): e0124595. Bibcode:2015PLoSO..1024595R. doi:10.1371/journal.pone.0124595. PMC 4405337. PMID 25897961.
  3. ^ Oxyclozanide MSDS


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