PAAF1

Protein-coding gene in the species Homo sapiens
PAAF1
Identifiers
AliasesPAAF1, PAAF, Rpn14, WDR71, proteasomal ATPase associated factor 1
External IDsHomoloGene: 49821; GeneCards: PAAF1; OMA:PAAF1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PAAF1
Genomic location for PAAF1
Band11q13.4Start73,876,699 bp[1]
End73,931,114 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • substantia nigra

  • internal globus pallidus

  • amygdala

  • external globus pallidus

  • putamen

  • pars reticulata

  • nucleus accumbens

  • inferior olivary nucleus

  • caudate nucleus
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • proteasome complex
Biological process
  • viral process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80227

n/a

Ensembl

ENSG00000175575

n/a

UniProt

Q9BRP4

n/a

RefSeq (mRNA)
NM_001267803
NM_001267804
NM_001267805
NM_001267806
NM_025155

NM_001363556

n/a

RefSeq (protein)
NP_001254732
NP_001254733
NP_001254734
NP_001254735
NP_079431

NP_001350485

n/a

Location (UCSC)Chr 11: 73.88 – 73.93 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Proteasomal ATPase-associated factor 1 is an enzyme that in humans is encoded by the PAAF1 gene.[3][4][5][6]

Interactions

PAAF1 has been shown to interact with PSMD10.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175575 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Park Y, Hwang YP, Lee JS, Seo SH, Yoon SK, Yoon JB (May 2005). "Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases". Molecular and Cellular Biology. 25 (9): 3842–53. doi:10.1128/MCB.25.9.3842-3853.2005. PMC 1084299. PMID 15831487.
  4. ^ Ponnappan S, Ovaa H, Ponnappan U (Mar 2007). "Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging". The International Journal of Biochemistry & Cell Biology. 39 (4): 799–809. doi:10.1016/j.biocel.2007.01.002. PMID 17317272.
  5. ^ Lassot I, Latreille D, Rousset E, Sourisseau M, Linares LK, Chable-Bessia C, Coux O, Benkirane M, Kiernan RE (Feb 2007). "The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms". Molecular Cell. 25 (3): 369–83. doi:10.1016/j.molcel.2006.12.020. PMID 17289585.
  6. ^ "Entrez Gene: WDR71 WD repeat domain 71".
  7. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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