PEX26

Protein-coding gene in the species Homo sapiens
PEX26
Identifiers
AliasesPEX26, PBD7A, PBD7B, PEX26M1T, Pex26pM1T, peroxisomal biogenesis factor 26
External IDsOMIM: 608666; MGI: 1921293; HomoloGene: 9922; GeneCards: PEX26; OMA:PEX26 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for PEX26
Genomic location for PEX26
Band22q11.21Start18,077,923 bp[1]
End18,105,396 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for PEX26
Genomic location for PEX26
Band6|6 F1Start121,160,626 bp[2]
End121,175,796 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • tendon of biceps brachii

  • islet of Langerhans

  • prefrontal cortex

  • rectum

  • ganglionic eminence

  • stromal cell of endometrium

  • anterior cingulate cortex

  • duodenum

  • ventricular zone
Top expressed in
  • secondary oocyte

  • Paneth cell

  • primary oocyte

  • lacrimal gland

  • left lung lobe

  • medullary collecting duct

  • hair follicle

  • left lobe of liver

  • otic vesicle

  • transitional epithelium of urinary bladder
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ATPase binding
  • protein C-terminus binding
  • protein binding
  • protein-containing complex binding
Cellular component
  • integral component of membrane
  • peroxisome
  • membrane
  • integral component of peroxisomal membrane
  • peroxisomal membrane
Biological process
  • protein transport
  • protein import into peroxisome matrix
  • protein import into peroxisome membrane
  • protein targeting to peroxisome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55670

74043

Ensembl

ENSG00000215193

ENSMUSG00000067825

UniProt

Q7Z412

Q8BGI5

RefSeq (mRNA)

NM_017929
NM_001127649
NM_001199319

NM_028730
NM_001304773
NM_001304774

RefSeq (protein)

NP_001121121
NP_001186248
NP_060399
NP_001121121.1
NP_060399.1

NP_001291702
NP_001291703
NP_083006

Location (UCSC)Chr 22: 18.08 – 18.11 MbChr 6: 121.16 – 121.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.[5][6][7]

Interactions

PEX26 has been shown to interact with PEX1,[5] PEX6[5] and SUFU.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000215193 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067825 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Matsumoto N, Tamura S, Fujiki Y (May 2003). "The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes". Nature Cell Biology. 5 (5): 454–60. doi:10.1038/ncb982. PMID 12717447. S2CID 2426040.
  6. ^ Matsumoto N, Tamura S, Furuki S, Miyata N, Moser A, Shimozawa N, Moser HW, Suzuki Y, Kondo N, Fujiki Y (Aug 2003). "Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation". American Journal of Human Genetics. 73 (2): 233–46. doi:10.1086/377004. PMC 1180364. PMID 12851857.
  7. ^ "Entrez Gene: PEX26 peroxisome biogenesis factor 26".
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (Mar 2005). "Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis". Journal of Molecular Biology. 346 (5): 1275–86. doi:10.1016/j.jmb.2005.01.013. PMID 15713480.
  • Weller S, Cajigas I, Morrell J, Obie C, Steel G, Gould SJ, Valle D (Jun 2005). "Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis". American Journal of Human Genetics. 76 (6): 987–1007. doi:10.1086/430637. PMC 1196456. PMID 15858711.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Furuki S, Tamura S, Matsumoto N, Miyata N, Moser A, Moser HW, Fujiki Y (Jan 2006). "Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex". The Journal of Biological Chemistry. 281 (3): 1317–23. doi:10.1074/jbc.M510044200. PMID 16257970.
  • Halbach A, Landgraf C, Lorenzen S, Rosenkranz K, Volkmer-Engert R, Erdmann R, Rottensteiner H (Jun 2006). "Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites". Journal of Cell Science. 119 (Pt 12): 2508–17. doi:10.1242/jcs.02979. PMID 16763195. S2CID 20304149.
  • Tamura S, Yasutake S, Matsumoto N, Fujiki Y (Sep 2006). "Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p". The Journal of Biological Chemistry. 281 (38): 27693–704. doi:10.1074/jbc.M605159200. PMID 16854980.
  • GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
  • OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum


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