PIK3R5

Protein-coding gene in the species Homo sapiens

PIK3R5
Identifiers
AliasesPIK3R5, F730038I15Rik, FOAP-2, P101-PI3K, p101, phosphoinositide-3-kinase regulatory subunit 5
External IDsOMIM: 611317; MGI: 2443588; HomoloGene: 8627; GeneCards: PIK3R5; OMA:PIK3R5 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for PIK3R5
Genomic location for PIK3R5
Band17p13.1Start8,878,911 bp[1]
End8,965,712 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for PIK3R5
Genomic location for PIK3R5
Band11|11 B3Start68,322,947 bp[2]
End68,388,675 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • blood

  • monocyte

  • spleen

  • bone marrow cells

  • upper lobe of left lung

  • lymph node

  • right lung

  • appendix

  • gallbladder
Top expressed in
  • granulocyte

  • thymus

  • blood

  • mesenteric lymph nodes

  • stroma of bone marrow

  • spleen

  • outer nuclear layer

  • otic vesicle

  • subcutaneous adipose tissue

  • lumbar subsegment of spinal cord
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G-protein beta/gamma-subunit complex binding
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
  • 1-phosphatidylinositol-3-kinase regulator activity
Cellular component
  • cytoplasm
  • plasma membrane
  • phosphatidylinositol 3-kinase complex, class IB
  • membrane
  • nucleus
  • phosphatidylinositol 3-kinase complex
  • microtubule organizing center
  • cytosol
Biological process
  • platelet activation
  • positive regulation of protein kinase B signaling
  • regulation of phosphatidylinositol 3-kinase activity
  • positive regulation of MAP kinase activity
  • phosphatidylinositol 3-kinase signaling
  • phosphatidylinositol phosphate biosynthetic process
  • G protein-coupled receptor signaling pathway
  • positive regulation of phosphatidylinositol 3-kinase signaling
  • phosphatidylinositol biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23533

320207

Ensembl

ENSG00000141506

ENSMUSG00000020901

UniProt

Q8WYR1

Q5SW28

RefSeq (mRNA)
NM_001142633
NM_001251851
NM_001251852
NM_001251853
NM_001251855

NM_014308
NM_001388396
NM_001388397
NM_001388398
NM_001388399
NM_001388400

NM_177320

RefSeq (protein)
NP_001136105
NP_001238780
NP_001238781
NP_001238782
NP_001238784

NP_055123

NP_796294.2
NP_796294

Location (UCSC)Chr 17: 8.88 – 8.97 MbChr 11: 68.32 – 68.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.[5][6]

Interactions

PIK3R5 has been shown to interact with PIK3CG.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141506 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020901 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Brock C, Schaefer M, Reusch HP, et al. (Jan 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J Cell Biol. 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.
  6. ^ "Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101".

Further reading

  • Johnson C, Marriott SJ, Levy LS (2007). "Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival". Oncogene. 26 (49): 7049–57. doi:10.1038/sj.onc.1210504. PMID 17486067.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Suire S, Coadwell J, Ferguson GJ, et al. (2005). "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma". Curr. Biol. 15 (6): 566–70. Bibcode:2005CBio...15..566S. doi:10.1016/j.cub.2005.02.020. PMID 15797027. S2CID 12255918.
  • Voigt P, Brock C, Nürnberg B, et al. (2005). "Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma". J. Biol. Chem. 280 (6): 5121–7. doi:10.1074/jbc.M413104200. PMID 15611065.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Metjian A, Roll RL, Ma AD, et al. (1999). "Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus". J. Biol. Chem. 274 (39): 27943–7. doi:10.1074/jbc.274.39.27943. PMID 10488142.
  • Krugmann S, Hawkins PT, Pryer N, et al. (1999). "Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits". J. Biol. Chem. 274 (24): 17152–8. doi:10.1074/jbc.274.24.17152. PMID 10358071.


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