PIP4K2C

Protein-coding gene in the species Homo sapiens

PIP4K2C

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2GK9

Identifiers

Aliases

PIP4K2C, PIP5K2C, phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

External IDs

OMIM: 617104; MGI: 2152214; HomoloGene: 23484; GeneCards: PIP4K2C; OMA:PIP4K2C - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.3	Start	57,591,174 bp^[1]
Band	12q13.3	End	57,603,418 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D3	Start	127,032,936 bp^[2]
Band	10\|10 D3	End	127,047,454 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

corpus epididymis

secondary oocyte

hair follicle

renal medulla

Region I of hippocampus proper

pons

nasal epithelium

buccal mucosa cell

nipple

islet of Langerhans

Top expressed in

retinal pigment epithelium

neural layer of retina

primary motor cortex

pyloric antrum

human kidney

prefrontal cortex

epithelium of stomach

submandibular gland

parotid gland

CA3 field

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding kinase activity phosphatidylinositol phosphate kinase activity identical protein binding ATP binding 1-phosphatidylinositol-5-phosphate 4-kinase activity
Cellular component	cytoplasm cytosol membrane autophagosome extracellular exosome
Biological process	phosphatidylinositol metabolic process positive regulation of autophagosome assembly phosphorylation phosphatidylinositol phosphate biosynthetic process regulation of autophagy phosphatidylinositol biosynthetic process regulation of phosphatidylinositol 3-kinase signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79837


117150

Ensembl


ENSG00000166908


ENSMUSG00000025417

UniProt


Q8TBX8


Q91XU3

RefSeq (mRNA)


NM_001146258 NM_001146259 NM_001146260 NM_024779


NM_054097 NM_001359280

RefSeq (protein)


NP_001139730 NP_001139731 NP_001139732 NP_079055


NP_473438 NP_001346209

Location (UCSC)

Chr 12: 57.59 – 57.6 Mb

Chr 10: 127.03 – 127.05 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma is an enzyme in humans that is encoded by the PIP4K2C gene.^[5] It is one of the phosphatidylinositol 4-phosphate 5-kinases.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166908 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025417 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma".

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C)

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- Gluco- Fructo- Hepatic Galacto- Phosphofructo- 1 Liver Muscle Platelet 2 Riboflavin Shikimate Thymidine ADP-thymidine NAD⁺ Glycerol Pantothenate Mevalonate Pyruvate Deoxycytidine PFP Diacylglycerol Phosphoinositide 3 Class I PI 3 Class II PI 3 Sphingosine Glucose-1,6-bisphosphate synthase
2.7.2: COOH acceptor	Phosphoglycerate Aspartate kinase
2.7.3: N acceptor	Creatine
2.7.4: PO₄ acceptor	Phosphomevalonate Adenylate Nucleoside-diphosphate Uridylate Guanylate Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase I/A γ θ ν T7 Taq II/B α δ ε ζ Pfu III/C IV/X β λ μ TDT V/Y η ι κ RNA-directed DNA polymerase Reverse transcriptase Telomerase
RNA polymerase	Template-directed RNA polymerase I II III IV V ssRNAP POLRMT Primase 1 2 PrimPol RNA-dependent RNA polymerase Polyadenylation PAP PNPase

Phosphorolytic
3' to 5' exoribonuclease

Nucleotidyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase CDP-diacylglycerol—serine O-phosphatidyltransferase CDP-diacylglycerol—inositol 3-phosphatidyltransferase CDP-diacylglycerol—choline O-phosphatidyltransferase
Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases
2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases
2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases
2.7.13: protein-histidine	Protein-histidine pros-kinase Protein-histidine tele-kinase Histidine kinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)