PLXNB1

Protein-coding gene in the species Homo sapiens
PLXNB1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2JPH, 2OS6, 2R2O, 2REX, 3HM6, 3OL2, 3SU8, 3SUA

Identifiers
AliasesPLXNB1, PLEXIN-B1, PLXN5, SEP, plexin B1
External IDsOMIM: 601053; MGI: 2154238; HomoloGene: 130508; GeneCards: PLXNB1; OMA:PLXNB1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PLXNB1
Genomic location for PLXNB1
Band3p21.31Start48,403,854 bp[1]
End48,430,086 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for PLXNB1
Genomic location for PLXNB1
Band9|9 F2Start108,924,457 bp[2]
End108,948,985 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • popliteal artery

  • tibial arteries

  • gastric mucosa

  • ventricular zone

  • skin of abdomen

  • skin of leg

  • right coronary artery
Top expressed in
  • otic vesicle

  • neural layer of retina

  • lumbar subsegment of spinal cord

  • Rostral migratory stream

  • medullary collecting duct

  • ventricular zone

  • otolith organ

  • utricle

  • retinal pigment epithelium

  • lip
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • GTPase activating protein binding
  • semaphorin receptor activity
  • semaphorin receptor binding
  • protein binding
  • transmembrane signaling receptor activity
  • GTPase activator activity
  • signaling receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • semaphorin receptor complex
  • integral component of plasma membrane
  • extracellular region
  • intracellular anatomical structure
Biological process
  • ossification involved in bone maturation
  • negative regulation of cell adhesion
  • neuron projection morphogenesis
  • intracellular signal transduction
  • positive regulation of axonogenesis
  • positive regulation of GTPase activity
  • regulation of cell shape
  • axon extension
  • negative regulation of osteoblast proliferation
  • positive regulation of phosphatidylinositol 3-kinase signaling
  • cell migration
  • regulation of cytoskeleton organization
  • semaphorin-plexin signaling pathway
  • signal transduction
  • semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
  • regulation of GTPase activity
  • G protein-coupled receptor signaling pathway
  • regulation of cell migration
  • semaphorin-plexin signaling pathway involved in axon guidance
  • inhibitory synapse assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5364

235611

Ensembl

ENSG00000164050

ENSMUSG00000053646

UniProt

O43157

Q8CJH3

RefSeq (mRNA)

NM_001130082
NM_002673

NM_172775

RefSeq (protein)

NP_001123554
NP_002664

NP_766363

Location (UCSC)Chr 3: 48.4 – 48.43 MbChr 9: 108.92 – 108.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.[5][6][7]

Function

Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.[8] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.[9]

Interactions

PLXNB1 has been shown to interact with ARHGEF12,[10] Rnd1[11] and ARHGEF11.[10][11][12][13]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164050 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053646 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
  6. ^ Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner". Proc Natl Acad Sci U S A. 97 (23): 12457–62. Bibcode:2000PNAS...9712457V. doi:10.1073/pnas.220421797. PMC 18785. PMID 11035813.
  7. ^ "Entrez Gene: PLXNB1 plexin B1".
  8. ^ Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Letters. 529 (2–3): 168–72. doi:10.1016/s0014-5793(02)03323-9. PMID 12372594. S2CID 26525009.
  9. ^ Basile JR, Afkhami T, Gutkind JS (Aug 2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway". Molecular and Cellular Biology. 25 (16): 6889–98. doi:10.1128/mcb.25.16.6889-6898.2005. PMC 1190270. PMID 16055703.
  10. ^ a b Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
  11. ^ a b Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
  12. ^ Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  13. ^ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608. S2CID 18981429.
  • Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A and Keegan AD. "Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1". ImmunoHorizons, February 1, 2019, 3 (2) 71-87; doi:10.4049/immunohorizons.1800026

Further reading

  • Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  • Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
  • Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMC 186329. PMID 11937491.
  • Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608. S2CID 18981429.
  • Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  • Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL (2002). "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12085–90. Bibcode:2002PNAS...9912085A. doi:10.1073/pnas.142433199. PMC 129402. PMID 12196628.
  • Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PM (2002). "The semaphorin 4D receptor controls invasive growth by coupling with Met". Nat. Cell Biol. 4 (9): 720–4. doi:10.1038/ncb843. PMID 12198496. S2CID 130071.
  • Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
  • Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M, Giordano S, Ghia P, Caligaris-Cappio F (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes". Blood. 101 (5): 1962–9. doi:10.1182/blood-2002-05-1339. PMID 12406905.
  • Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
  • Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
  • Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
  • Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888. S2CID 24596233.
  • Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2". J. Cell Biol. 165 (6): 869–80. doi:10.1083/jcb.200312094. PMC 2172401. PMID 15210733.
  • Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science. 305 (5685): 862–5. Bibcode:2004Sci...305..862O. doi:10.1126/science.1097545. PMID 15297673. S2CID 39544623.
  • Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM, Bussolino F, Giordano S (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1". Blood. 105 (11): 4321–9. doi:10.1182/blood-2004-07-2885. PMID 15632204.
  • Overview of all the structural information available in the PDB for UniProt: O43157 (Plexin-B1) at the PDBe-KB.


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