PLXNB2

Protein-coding gene in the species Homo sapiens
PLXNB2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4E71

Identifiers
AliasesPLXNB2, MM1, Nbla00445, PLEXB2, dJ402G11.3, plexin B2
External IDsOMIM: 604293; MGI: 2154239; HomoloGene: 66630; GeneCards: PLXNB2; OMA:PLXNB2 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for PLXNB2
Genomic location for PLXNB2
Band22q13.33Start50,274,979 bp[1]
End50,307,646 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for PLXNB2
Genomic location for PLXNB2
Band15 E3|15 44.68 cMStart89,039,752 bp[2]
End89,064,991 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • right hemisphere of cerebellum

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • anterior pituitary

  • stromal cell of endometrium

  • nasal epithelium

  • body of stomach

  • olfactory zone of nasal mucosa

  • decidua
Top expressed in
  • pyloric antrum

  • choroid plexus of fourth ventricle

  • calvaria

  • corneal stroma

  • genital tubercle

  • epithelium of stomach

  • stroma of bone marrow

  • ventricular zone

  • conjunctival fornix

  • Rostral migratory stream
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • semaphorin receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • cell surface
  • extracellular exosome
  • integral component of plasma membrane
  • semaphorin receptor complex
Biological process
  • regulation of protein phosphorylation
  • negative regulation of cell adhesion
  • regulation of GTPase activity
  • positive regulation of axonogenesis
  • multicellular organism development
  • neural tube closure
  • brain development
  • regulation of cell shape
  • neuroblast proliferation
  • regulation of neuron migration
  • semaphorin-plexin signaling pathway
  • signal transduction
  • positive regulation of neuron projection development
  • homophilic cell adhesion via plasma membrane adhesion molecules
  • regulation of cell migration
  • semaphorin-plexin signaling pathway involved in axon guidance
  • excitatory synapse assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23654

140570

Ensembl

ENSG00000196576

ENSMUSG00000036606

UniProt

O15031

B2RXS4

RefSeq (mRNA)

NM_012401

NM_001159521
NM_001284506
NM_138749

RefSeq (protein)
NP_036533
NP_001363793
NP_001363794
NP_001363795
NP_001363796

NP_001363797
NP_001363798
NP_001363799
NP_001363800
NP_001363801
NP_001363802
NP_001363803
NP_001363804
NP_001363805
NP_001363806
NP_001363807
NP_001363808
NP_001363809
NP_001363810
NP_001363811
NP_001363812
NP_001363813
NP_001363814
NP_001363815

NP_001152993
NP_001271435
NP_620088

Location (UCSC)Chr 22: 50.27 – 50.31 MbChr 15: 89.04 – 89.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.[5][6][7]

Function

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM][7]

Interactions

PLXNB2 has been shown to interact with ARHGEF11.[6][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196576 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036606 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
  6. ^ a b Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  7. ^ a b "Entrez Gene: PLXNB2 plexin B2".
  8. ^ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

Further reading

  • Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG (1995). "Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors". Cancer Lett. 89 (2): 215–21. doi:10.1016/0304-3835(95)03690-X. PMID 7889532.
  • Trofatter JA, Long KR, Murrell JR, Stotler CJ, Gusella JF, Buckler AJ (1996). "An expression-independent catalog of genes from human chromosome 22". Genome Res. 5 (3): 214–24. doi:10.1101/gr.5.3.214. PMID 8593609.
  • Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
  • Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.


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