PPIH

Protein-coding gene in the species Homo sapiens
PPIH
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1MZW, 1QOI

Identifiers
AliasesPPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDsOMIM: 606095; MGI: 106499; HomoloGene: 38172; GeneCards: PPIH; OMA:PPIH - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PPIH
Genomic location for PPIH
Band1p34.2Start42,658,335 bp[1]
End42,676,758 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for PPIH
Genomic location for PPIH
Band4 D2.1|4 55.34 cMStart119,157,207 bp[2]
End119,177,743 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • embryo

  • ventricular zone

  • ganglionic eminence

  • mucosa of transverse colon

  • granulocyte

  • secondary oocyte

  • rectum

  • mucosa of esophagus

  • olfactory zone of nasal mucosa

  • lymph node
Top expressed in
  • ventricular zone

  • embryo

  • spermatocyte

  • embryo

  • yolk sac

  • morula

  • blastocyst

  • spermatid

  • genital tubercle

  • zygote
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ribonucleoprotein complex binding
  • isomerase activity
  • protein binding
  • peptidyl-prolyl cis-trans isomerase activity
  • cyclosporin A binding
  • unfolded protein binding
Cellular component
  • cytoplasm
  • nuclear speck
  • U4/U6 x U5 tri-snRNP complex
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • U4/U6 snRNP
Biological process
  • mRNA splicing, via spliceosome
  • mRNA processing
  • positive regulation of viral genome replication
  • protein folding
  • RNA splicing
  • protein-containing complex assembly
  • protein peptidyl-prolyl isomerization
  • angiogenesis
  • protein refolding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10465

66101

Ensembl

ENSG00000171960

ENSMUSG00000060288

UniProt

O43447

Q9D868

RefSeq (mRNA)

NM_006347
NM_001330510

NM_001110129
NM_001110130
NM_028677

RefSeq (protein)

NP_001317439
NP_006338

NP_001103599
NP_001103600
NP_082953

Location (UCSC)Chr 1: 42.66 – 42.68 MbChr 4: 119.16 – 119.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.[5][6][7]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171960 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060288 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.
  6. ^ Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins". RNA. 4 (2): 127–41. PMC 1369602. PMID 9570313.
  7. ^ a b "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)".

Further reading

  • Reidt U, Reuter K, Achsel T, et al. (2000). "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin" (PDF). J. Biol. Chem. 275 (11): 7439–42. doi:10.1074/jbc.275.11.7439. PMID 10713041. S2CID 20261807.
  • Horowitz DS, Lee EJ, Mabon SA, Misteli T (2002). "A cyclophilin functions in pre-mRNA splicing". EMBO J. 21 (3): 470–80. doi:10.1093/emboj/21.3.470. PMC 125845. PMID 11823439.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Reidt U, Wahl MC, Fasshauer D, et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. hdl:11858/00-001M-0000-0012-F238-B. PMID 12875835.
  • Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004). "Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH". Nucleic Acids Res. 31 (16): 4791–6. doi:10.1093/nar/gkg660. PMC 169899. PMID 12907720.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • v
  • t
  • e
  • 1mzw: Crystal structure of a U4/U6 snRNP complex between human spliceosomal cyclophilin H and a U4/U6-60K peptide
    1mzw: Crystal structure of a U4/U6 snRNP complex between human spliceosomal cyclophilin H and a U4/U6-60K peptide
  • 1qoi: U4/U6 SNRNP-SPECIFIC CYCLOPHILIN SNUCYP-20
    1qoi: U4/U6 SNRNP-SPECIFIC CYCLOPHILIN SNUCYP-20


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