PPIL4

Protein-coding gene in the species Homo sapiens
PPIL4
Identifiers
AliasesPPIL4, HDCME13P, peptidylprolyl isomerase like 4
External IDsOMIM: 607609; MGI: 1914668; HomoloGene: 12126; GeneCards: PPIL4; OMA:PPIL4 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PPIL4
Genomic location for PPIL4
Band6q25.1Start149,504,495 bp[1]
End149,546,043 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for PPIL4
Genomic location for PPIL4
Band10|10 A1Start7,668,655 bp[2]
End7,698,899 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • epithelium of colon

  • testicle

  • left ovary

  • gonad

  • ventricular zone

  • right ovary

  • endometrium

  • islet of Langerhans

  • thymus
Top expressed in
  • saccule

  • otic vesicle

  • otic placode

  • zygote

  • primitive streak

  • granulocyte

  • pituitary gland

  • seminal vesicula

  • neural layer of retina

  • blood
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • isomerase activity
  • nucleic acid binding
  • RNA binding
  • peptidyl-prolyl cis-trans isomerase activity
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • protein peptidyl-prolyl isomerization
  • regulation of phosphorylation of RNA polymerase II C-terminal domain
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

85313

67418

Ensembl

ENSG00000131013

ENSMUSG00000015757

UniProt

Q8WUA2

Q9CXG3

RefSeq (mRNA)

NM_139126

NM_026141

RefSeq (protein)

NP_624311

NP_080417

Location (UCSC)Chr 6: 149.5 – 149.55 MbChr 10: 7.67 – 7.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the PPIL4 gene.[5]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131013 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015757 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4".

Further reading

  • Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain". Cytogenet. Cell Genet. 95 (1–2): 43–7. doi:10.1159/000057015. PMID 11978968. S2CID 35018873.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • v
  • t
  • e