PPP6R3

The PPP6R3 gene (also termed C11orf23, PP6R3, SAP190, SAPL, SAPLa, and SAPS3[1]) is located at band 13.2 on the long (or "q") arm of chromosome 11 and is expressed in all tissues tested in humans.[2] It encodes protein phosphatase 6 regulatory subunit 3 (PP6RS3).[3] Also termed serine/threonine-protein phosphatase 6 regulatory subunit 3, PP6RS3 is the function-regulating subunit of protein phosphatase 6 (PPP6C).[4] PPP6C is a component of a signaling pathway that regulates various cell functions including cell division, the repair of damaged DNA, inflammatory responses,[5] messenger mRNA splicing, and the stability of chromosomes.[6]

Two cases of nodular fasciitis have malignant tumors in which the neoplastic cells expressed a PPP6R3 gene merged to the USP6 (i.e. ubiquitin carboxyl-terminal hydrolase 6) gene to form an USP-PPP6R3 fusion gene. In both of these cases, the USP-PPP6R3 fusion genes was considered to contribute to these tumors malignancy.[3][6][7]

References

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  3. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2083: attempt to index a boolean value.
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  6. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2083: attempt to index a boolean value.
  7. ^ Lua error in Module:Citation/CS1/Configuration at line 2083: attempt to index a boolean value.
  • Atlas of Genetics

PPPR63

GeneCard for PPP6R3


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