PTPMT1

Protein-coding gene in the species Homo sapiens
PTPMT1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3RGO, 3RGQ

Identifiers
AliasesPTPMT1, DUSP23, MOSP, PLIP, PNAS-129, protein tyrosine phosphatase, mitochondrial 1, protein tyrosine phosphatase mitochondrial 1
External IDsOMIM: 609538; MGI: 1913711; HomoloGene: 11973; GeneCards: PTPMT1; OMA:PTPMT1 - orthologs
EC number3.1.3.48
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PTPMT1
Genomic location for PTPMT1
Band11p11.2Start47,565,430 bp[1]
End47,573,461 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PTPMT1
Genomic location for PTPMT1
Band2|2 E1Start90,739,060 bp[2]
End90,748,389 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • putamen

  • left adrenal cortex

  • substantia nigra

  • hypothalamus

  • right adrenal gland

  • caudate nucleus

  • right adrenal cortex

  • nucleus accumbens
Top expressed in
  • left ventricle

  • interventricular septum

  • quadriceps femoris muscle

  • spermatid

  • white adipose tissue

  • testicle

  • peripheral nervous system

  • superior cervical ganglion

  • muscle tissue

  • muscle of thigh
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphoprotein phosphatase activity
  • phosphatase activity
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
  • protein binding
  • phosphatidylglycerophosphatase activity
  • protein tyrosine phosphatase activity
  • hydrolase activity
  • protein tyrosine/serine/threonine phosphatase activity
Cellular component
  • membrane
  • mitochondrion
  • mitochondrial inner membrane
  • nucleus
Biological process
  • lipid metabolism
  • protein dephosphorylation
  • phospholipid biosynthetic process
  • cardiolipin biosynthetic process
  • peptidyl-tyrosine dephosphorylation
  • dephosphorylation
  • phosphatidylglycerol biosynthetic process
  • regulation of intrinsic apoptotic signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114971

66461

Ensembl

ENSG00000110536
ENSG00000285206

ENSMUSG00000063235

UniProt

Q8WUK0

Q66GT5

RefSeq (mRNA)

NM_175732
NM_001143984

NM_025576

RefSeq (protein)

NP_001137456
NP_783859

NP_079852

Location (UCSC)Chr 11: 47.57 – 47.57 MbChr 2: 90.74 – 90.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein tyrosine phosphatase, mitochondrial 1 is a protein in humans that is primarily coded by the gene PTPMT1 gene. [5]

References

  1. ^ a b c ENSG00000285206 GRCh38: Ensembl release 89: ENSG00000110536, ENSG00000285206 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063235 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Protein tyrosine phosphatase, mitochondrial 1". Retrieved 2017-01-12.

Further reading

  • Niemi NM, Lanning NJ, Westrate LM, MacKeigan JP (2013). "Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death". PLOS ONE. 8 (1): e53803. Bibcode:2013PLoSO...853803N. doi:10.1371/journal.pone.0053803. PMC 3542197. PMID 23326511.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)


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