Perafensine
Chemical compound
- None
- Abandoned
- 1-phenyl-3-(1-piperazinyl)isoquinoline
- 72444-62-3
- 3047830
- 2310140
- WU6989IN6X
- DTXSID40222744
- Interactive image
- c1ccc(cc1)c2c3ccccc3cc(n2)N4CCNCC4
InChI
- InChI=1S/C19H19N3/c1-2-6-15(7-3-1)19-17-9-5-4-8-16(17)14-18(21-19)22-12-10-20-11-13-22/h1-9,14,20H,10-13H2
- Key:BHHDTFRLKOTSKW-UHFFFAOYSA-N
Perafensine (INN) (code name HR-459) is a drug which was investigated as an antidepressant but was never marketed.[1] It has been reported to antagonize the effects of reserpine and to inhibit the reuptake of norepinephrine (norepinephrine reuptake inhibitor); whether it also affects the reuptake of serotonin or dopamine is unclear.[2]
See also
References
- ^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1585–. ISBN 978-0-412-46630-4.
- ^ Bondinell W, Kaiser C (1982). Chapter 5. Antidepressants. Annual Reports in Medicinal Chemistry. Vol. 17. pp. 41–50. doi:10.1016/S0065-7743(08)60487-X. ISBN 9780120405176.
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(DRIsTooltip Dopamine reuptake inhibitors)
(NRIsTooltip Norepinephrine reuptake inhibitors)
(SRIsTooltip Serotonin reuptake inhibitors)
- Amiodarone
- Amphetamines (e.g., amphetamine, methamphetamine, MDMA)
- APP
- AZIK
- Bietaserpine
- Deserpidine
- Deutetrabenazine
- Dihydrotetrabenazine
- Efavirenz
- GBR-12935
- GZ-793A
- Ibogaine
- Ketanserin
- Lobeline
- Methoxytetrabenazine
- Reserpine
- Rose bengal
- Tetrabenazine
- Valbenazine
- Vanoxerine (GBR-12909)
- DAT enhancers: Luteolin
- DAT modulators: Agonist-like: SoRI-9804
- SoRI-20040; Antagonist-like: SoRI-20041
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins
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