Polyamine-modulated factor 1

Protein-coding gene in the species Homo sapiens
PMF1
Identifiers
AliasesPMF1, polyamine modulated factor 1
External IDsOMIM: 609176; MGI: 1914287; HomoloGene: 5224; GeneCards: PMF1; OMA:PMF1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PMF1
Genomic location for PMF1
Band1q22Start156,212,993 bp[1]
End156,240,042 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for PMF1
Genomic location for PMF1
Band3|3 F1Start88,301,450 bp[2]
End88,317,638 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • apex of heart

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • gastrocnemius muscle

  • right auricle

  • ectocervix

  • skin of leg

  • left ventricle

  • granulocyte
Top expressed in
  • yolk sac

  • embryo

  • embryo

  • ventricular zone

  • tibiofemoral joint

  • blastocyst

  • internal carotid artery

  • lip

  • morula

  • epiblast
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transcription coactivator activity
  • leucine zipper domain binding
  • protein binding
Cellular component
  • chromosome
  • cytosol
  • MIS12/MIND type complex
  • chromosome, centromeric region
  • nucleus
  • kinetochore
  • transcription regulator complex
  • nucleoplasm
  • Golgi apparatus
  • intracellular membrane-bounded organelle
  • nuclear MIS12/MIND complex
Biological process
  • chromosome segregation
  • cell division
  • cell cycle
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11243

67037

Ensembl

ENSG00000160783

ENSMUSG00000028066

UniProt

Q6P1K2

Q9CPV5

RefSeq (mRNA)

NM_007221
NM_001199653
NM_001199654

NM_025928
NM_001310605

RefSeq (protein)

NP_001186582
NP_001186583
NP_009152

NP_001297534
NP_080204

Location (UCSC)Chr 1: 156.21 – 156.24 MbChr 3: 88.3 – 88.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.[5][6]

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160783 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028066 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.
  6. ^ "Entrez Gene: PMF1 polyamine-modulated factor 1".
  7. ^ Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  8. ^ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.

Further reading

  • Wang Y, Devereux W, Stewart TM, Casero RA (April 2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". The Biochemical Journal. 355 (Pt 1): 45–9. doi:10.1042/0264-6021:3550045. PMC 1221710. PMID 11256947.
  • Wang Y, Devereux W, Stewart TM, Casero RA (August 2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". The Biochemical Journal. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
  • Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  • Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
  • Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A (April 2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". The Journal of Cell Biology. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.
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