Protein-coding gene in the species Homo sapiens
ROCK2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4L6Q, 4WOT |
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Identifiers |
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Aliases | ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2 |
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External IDs | OMIM: 604002; MGI: 107926; HomoloGene: 21010; GeneCards: ROCK2; OMA:ROCK2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2p25.1 | Start | 11,179,759 bp[1] |
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End | 11,348,330 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 12 (mouse)[2] |
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| Band | 12|12 A1.1 | Start | 16,894,895 bp[2] |
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End | 16,987,823 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Achilles tendon
- epithelium of colon
- middle temporal gyrus
- thoracic diaphragm
- biceps brachii
- superficial temporal artery
- Skeletal muscle tissue of biceps brachii
- Brodmann area 10
- cerebellar vermis
- Brodmann area 46
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| Top expressed in | - tail of embryo
- aortic valve
- ascending aorta
- muscle of thigh
- dentate gyrus of hippocampal formation granule cell
- genital tubercle
- superior frontal gyrus
- triceps brachii muscle
- primary visual cortex
- thoracic diaphragm
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - transferase activity
- nucleotide binding
- protein kinase activity
- structural molecule activity
- metal ion binding
- kinase activity
- protein serine/threonine kinase activity
- protein binding
- ATP binding
- Rho-dependent protein serine/threonine kinase activity
- RNA binding
- tau protein binding
- tau-protein kinase activity
| Cellular component | - cytoplasm
- centrosome
- membrane
- plasma membrane
- microtubule organizing center
- cytoplasmic ribonucleoprotein granule
- cytoskeleton
- nucleus
- cytosol
- intracellular anatomical structure
| Biological process | - smooth muscle contraction
- positive regulation of protein phosphorylation
- intracellular signal transduction
- regulation of actin cytoskeleton organization
- centrosome duplication
- phosphorylation
- rhythmic process
- ephrin receptor signaling pathway
- cellular response to testosterone stimulus
- cytokinesis
- positive regulation of centrosome duplication
- regulation of stress fiber assembly
- regulation of cell motility
- positive regulation of endothelial cell migration
- protein phosphorylation
- negative regulation of bicellular tight junction assembly
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of gene expression
- regulation of cell adhesion
- regulation of circadian rhythm
- Rho protein signal transduction
- regulation of focal adhesion assembly
- negative regulation of angiogenesis
- regulation of keratinocyte differentiation
- negative regulation of myosin-light-chain-phosphatase activity
- I-kappaB kinase/NF-kappaB signaling
- regulation of establishment of cell polarity
- cortical actin cytoskeleton organization
- regulation of establishment of endothelial barrier
- actin cytoskeleton organization
- protein localization to plasma membrane
- G protein-coupled receptor signaling pathway
- aortic valve morphogenesis
- positive regulation of cardiac muscle hypertrophy
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- positive regulation of cell migration
- positive regulation of connective tissue growth factor production
- positive regulation of MAPK cascade
- regulation of protein metabolic process
- positive regulation of stress fiber assembly
- negative regulation of biomineral tissue development
- response to transforming growth factor beta
- positive regulation of fibroblast growth factor production
- regulation of angiotensin-activated signaling pathway
- negative regulation of protein localization to lysosome
- positive regulation of amyloid-beta formation
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- positive regulation of protein localization to early endosome
- positive regulation of amyloid precursor protein catabolic process
- positive regulation of connective tissue replacement
- response to angiotensin
- response to ischemia
- negative regulation of gene expression
- regulation of nervous system process
- negative regulation of nitric oxide biosynthetic process
- mRNA destabilization
- blood vessel diameter maintenance
- regulation of cellular response to hypoxia
- cellular response to acetylcholine
- mitotic cytokinesis
- actomyosin structure organization
- embryonic morphogenesis
- regulation of cell junction assembly
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 2: 11.18 – 11.35 Mb | Chr 12: 16.89 – 16.99 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [5]Fasudil is an inhibitor of ROCK protein.
Function
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134318 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020580 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.
Further reading
- Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
External links
- Overview of all the structural information available in the PDB for UniProt: O75116 (Human Rho-associated protein kinase 2 (ROCK2)) at the PDBe-KB.