RPP14

Protein-coding gene in the species Homo sapiens
RPP14
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3IR3

Identifiers
AliasesRPP14, P14, HsHTD2, ribonuclease P/MRP subunit p14
External IDsOMIM: 606112; MGI: 1914303; HomoloGene: 5113; GeneCards: RPP14; OMA:RPP14 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for RPP14
Genomic location for RPP14
Band3p14.3Start58,306,245 bp[1]
End58,324,695 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for RPP14
Genomic location for RPP14
Band14|14 A1Start14,377,939 bp[2]
End14,389,406 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • gonad

  • gastrocnemius muscle

  • Achilles tendon

  • mucosa of transverse colon

  • stromal cell of endometrium

  • testicle

  • epithelium of colon

  • ventricular zone

  • smooth muscle tissue
Top expressed in
  • ventricular zone

  • seminal vesicula

  • embryo

  • embryo

  • morula

  • sternocleidomastoid muscle

  • epiblast

  • temporal muscle

  • triceps brachii muscle

  • facial motor nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ribonuclease activity
  • hydrolase activity
  • RNA binding
  • ribonuclease P activity
  • lyase activity
  • 3-hydroxyacyl-CoA dehydratase activity
Cellular component
  • nucleus
  • nucleoplasm
  • multimeric ribonuclease P complex
  • nucleolus
  • mitochondrion
  • mitochondrial matrix
Biological process
  • RNA phosphodiester bond hydrolysis
  • RNA phosphodiester bond hydrolysis, endonucleolytic
  • tRNA processing
  • tRNA 5'-leader removal
  • fatty acid metabolic process
  • lipid metabolism
  • fatty-acyl-CoA biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11102

67053

Ensembl

ENSG00000163684

ENSMUSG00000023156

UniProt

O95059
P86397

Q9CQH8

RefSeq (mRNA)

NM_001098783
NM_007042

NM_025938

RefSeq (protein)
NP_001092253
NP_008973
NP_001335641
NP_001335642
NP_001335643

NP_001335644

NP_080214

Location (UCSC)Chr 3: 58.31 – 58.32 MbChr 14: 14.38 – 14.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonuclease P protein subunit p14 is an enzyme that in humans is encoded by the RPP14 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163684 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023156 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jarrous N, Eder PS, Wesolowski D, Altman S (Mar 1999). "Rpp14 and Rpp29, two protein subunits of human ribonuclease P". RNA. 5 (2): 153–157. doi:10.1017/S135583829800185X. PMC 1369747. PMID 10024167.
  6. ^ Jiang T, Altman S (Apr 2002). "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity". Proc Natl Acad Sci U S A. 99 (8): 5295–5300. doi:10.1073/pnas.072083699. PMC 122763. PMID 11929972.
  7. ^ "Entrez Gene: RPP14 ribonuclease P 14kDa subunit".

Further reading

  • Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–925. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–1351. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
  • Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–941. doi:10.1017/S1355838201010299. PMC 1370153. PMID 11455963.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–2146. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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