RPP38

Protein-coding gene in the species Homo sapiens
RPP38
Identifiers
AliasesRPP38, ribonuclease P/MRP subunit p38
External IDsOMIM: 606116; MGI: 2443607; HomoloGene: 4680; GeneCards: RPP38; OMA:RPP38 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for RPP38
Genomic location for RPP38
Band10p13Start15,097,180 bp[1]
End15,139,818 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for RPP38
Genomic location for RPP38
Band2|2 A1Start3,329,986 bp[2]
End3,333,680 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • bronchial epithelial cell

  • olfactory zone of nasal mucosa

  • right uterine tube

  • mucosa of transverse colon

  • sperm

  • nasal epithelium

  • oocyte

  • granulocyte
Top expressed in
  • primary oocyte

  • spermatocyte

  • secondary oocyte

  • genital tubercle

  • zygote

  • morula

  • epiblast

  • spermatid

  • tail of embryo

  • testicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • hydrolase activity
  • protein binding
  • ribonuclease P activity
Cellular component
  • nucleus
  • nucleolus
  • nucleoplasm
  • nucleolar ribonuclease P complex
  • fibrillar center
Biological process
  • RNA phosphodiester bond hydrolysis, endonucleolytic
  • RNA phosphodiester bond hydrolysis
  • tRNA processing
  • tRNA 5'-leader removal
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10557

227522

Ensembl

ENSG00000152464

ENSMUSG00000049950

UniProt

P78345
Q5VUC3

A2AJG0

RefSeq (mRNA)

NM_001097590
NM_001265601
NM_006414
NM_183005

NM_001013376

RefSeq (protein)

NP_001091059
NP_001252530
NP_006405
NP_892117

NP_001013394

Location (UCSC)Chr 10: 15.1 – 15.14 MbChr 2: 3.33 – 3.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonuclease P protein subunit p38 is an enzyme that in humans is encoded by the RPP38 gene.[5][6][7]

Interactions

RPP38 has been shown to interact with POP4.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152464 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049950 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Eder PS, Kekuda R, Stolc V, Altman S (March 1997). "Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1101–6. Bibcode:1997PNAS...94.1101E. doi:10.1073/pnas.94.4.1101. PMC 19751. PMID 9037013.
  6. ^ Jarrous N, Eder PS, Guerrier-Takada C, Hoog C, Altman S (June 1998). "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P". RNA. 4 (4): 407–17. PMC 1369627. PMID 9630247.
  7. ^ "Entrez Gene: RPP38 ribonuclease P/MRP 38kDa subunit".
  8. ^ Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Jarrous N, Wolenski JS, Wesolowski D, Lee C, Altman S (1999). "Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P". J. Cell Biol. 146 (3): 559–72. doi:10.1083/jcb.146.3.559. PMC 2150555. PMID 10444065.
  • Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–41. doi:10.1017/S1355838201010299. PMC 1370153. PMID 11455963.
  • Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


  • v
  • t
  • e