Protein-coding gene in the species Homo sapiens
RRAGB |
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Identifiers |
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Aliases | RRAGB, RAGB, bA465E19.1, Ras related GTP binding B |
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External IDs | OMIM: 300725; MGI: 3038613; HomoloGene: 48396; GeneCards: RRAGB; OMA:RRAGB - orthologs |
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Gene location (Mouse) |
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| Chr. | X chromosome (mouse)[1] |
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| Band | X|X F3 | Start | 151,922,977 bp[1] |
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End | 151,954,939 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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| Top expressed in | - hypothalamus
- hippocampus proper
- cerebellum
- epiblast
- cerebellar cortex
- dentate gyrus of hippocampal formation granule cell
- primary visual cortex
- Cortex of frontal lobe
- superior frontal gyrus
- olfactory bulb
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - nucleotide binding
- GTP binding
- protein binding
- guanyl ribonucleotide binding
- GTPase activity
- protein heterodimerization activity
- GTPase binding
| Cellular component | - cytoplasm
- cytosol
- lysosomal membrane
- lysosome
- nucleus
- Gtr1-Gtr2 GTPase complex
| Biological process | - regulation of TOR signaling
- cellular response to amino acid starvation
- cellular response to amino acid stimulus
- positive regulation of TOR signaling
- regulation of autophagy
- regulation of macroautophagy
- positive regulation of TORC1 signaling
- cellular response to leucine starvation
- cellular response to starvation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | |
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NP_006055 NP_057740 NP_001340940 NP_001340942 |
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Location (UCSC) | n/a | Chr X: 151.92 – 151.95 Mb |
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PubMed search | [2] | [3] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene.[4][5][6]
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. MTORC1 responds to amino acids via interaction with RAGB.[6]
References
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041658 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Schurmann A, Brauers A, Massmann S, Becker W, Joost HG (Jan 1996). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". J Biol Chem. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
- ^ Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Feb 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". J Cell Sci. 111. ( Pt 1): 11–21. doi:10.1242/jcs.111.1.11. PMID 9394008.
- ^ a b "Entrez Gene: RRAGB Ras-related GTP binding B".
Further reading
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–96. doi:10.1167/iovs.02-1099. PMID 12766061.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sekiguchi T, Hirose E, Nakashima N, et al. (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B." J. Biol. Chem. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.