Roussin's black salt
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Other names potassium heptanitrosyltri-μ3-thiotetraferrate | |
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Properties | |
Chemical formula | Fe4KN7O7S3 |
Molar mass | 568.70 g·mol−1 |
Appearance | Black solid |
Melting point | 198 to 200 °C (388 to 392 °F; 471 to 473 K) |
Related compounds | |
Related | Roussin's Red Salt |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Roussin's black salt is a chemical compound with the formula KFe4S3(NO)7.[1] It consists of the potassium salt of the [Fe4S3(NO)7]− anion, metal nitrosyl compound. First described by Zacharie Roussin in 1858,[2] it is one of the first synthetic iron-sulfur clusters along with the red salt also bearing his name.
Structure
The cluster anion has the geometry of an incomplete cubane-type cluster with C3v symmetry. The dark colour of the complex is attributed to a number of charge-transfer interactions.[3]
Synthesis
Roussin’s black salt is produced by the reaction of nitrous acid, potassium hydroxide, potassium sulfide, and iron(II) sulfate in aqueous solution.[4] It can also be formed by the conversion of Roussin's red salt in mildly acidic conditions. This reaction is reversible and Roussin’s red salt is reformed upon alkalization of the reaction solution.
Uses
Roussin’s black salt is a nitric oxide donor.[5] Also, Roussin’s Black Salt exhibits antibacterial activity in some food processing applications.[6]
See also
References
- ^ Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. p. 1094. ISBN 978-0-08-037941-8.
- ^ Butler, Anthony R. (July 1982). "The chemist Z. Roussin (1827-94)". Journal of Chemical Education. 59 (7): 549. Bibcode:1982JChEd..59..549B. doi:10.1021/ed059p549.
- ^ Jaworska, Maria; Stasicka, Zofia (March 2006). "Structure and UV–vis spectroscopy of roussin black salt [Fe4S3(NO)7]−". Journal of Molecular Structure. 785 (1–3): 68–75. Bibcode:2006JMoSt.785...68J. doi:10.1016/j.molstruc.2005.09.030.
- ^ Marchlewski, L.; Sachs, J. (1892). "Studien über ROUSINS Salz". Zeitschrift für anorganische Chemie. 2 (1): 175–181. doi:10.1002/zaac.18920020117.
- ^ Janczyk, Agnieszka; Wolnicka-Glubisz, Agnieszka; Chmura, Antonina; Elas, Martyna; Matuszak, Zenon; Stochel, Grazyna; Urbanska, Krystyna (February 2004). "NO-dependent phototoxicity of Roussin's black salt against cancer cells". Nitric Oxide. 10 (1): 42–50. doi:10.1016/j.niox.2004.01.009. PMID 15050534.
- ^ Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. pp. 1094–1095. ISBN 978-0-08-037941-8.
- v
- t
- e
- Nitroxyl anion (NO−; oxonitrate(1-), hyponitrite anion)
- Nitric oxide (NO⋅; nitrogen monoxide)
- Nitrosonium (NO+; nitrosyl cation)
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(prodrugs)
- Nitrates: Diethylene glycol dinitrate (DEGDN)
- Erythritol tetranitrate (ETN)
- Ethylene glycol dinitrate (EGDN; nitroglycol)
- Isosorbide mononitrate (ISMN)
- Isosorbide dinitrate (ISDN)
- Itramin tosilate
- Mannitol hexanitrate
- Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)
- NCX-466
- NCX-2216
- NCX-4016
- NCX 4040
- NCX-4215
- Nicorandil
- Nipradilol (K-351)
- Nitrate (NO−
3) - Nitroatorvastatin (NCX-6560)
- Nitroflurbiprofen (HCT-1026)
- Nitrofluvastatin
- Nitroglycerin (glyceryl trinitrate (GTN))
- Nitropravastatin (NCX-6550)
- Pentaerithrityl tetranitrate (PETN)
- Propatylnitrate
- Propylene glycol dinitrate (PGDN)
- Sodium trioxodinitrate (Angeli's salt)
- Tenitramine
- Trolnitrate
- Nitroso compounds/nitrites: Nitrite (NO−
2); O-Nitroso compounds (alkyl nitrites): Amyl nitrite (isoamyl nitrite, isopentyl nitrite) - Cyclohexyl nitrite
- Ethyl nitrite
- Hexyl nitrite
- Isobutyl nitrite (2-methylpropyl nitrite)
- Isopropyl nitrite
- Methyl nitrite
- n-Butyl nitrite
- Pentyl nitrite
- tert-Butyl nitrite; S-Nitroso compounds (thionitrites): LA810
- S-Nitrosoalbumin (SNALB)
- S-Nitrosated AR545C
- S-Nitroso-N-acetylcysteine (SNAC)
- S-Nitroso-N-acetylpenicillamine (SNAP)
- S-Nitroso-N-valerylpenicillamine (SNVP)
- S-Nitrosocaptopril (SNO-Cap)
- S-Nitrosocysteine (SNC, CysNO, SNO-Cys)
- S-Nitrosodiclofenac
- S-Nitrosoglutathione (GSNO, SNOG)
- SNO-t-PA
- SNO-vWF; N-Nitroso compounds (e.g., nitrosamines): SIN-1A
- Nitrosyl compounds: Metal nitrosyl complexes: Roussin's black salt
- Roussin's red salt
- Sodium nitroprusside (SNP)
- NONOates (diazeniumdiolates): Diethylamine/NO (DEA/NO)
- Diethylenetriamine/NO (DETA/NO)
- GLO/NO
- JS-K
- Methylamine hexamethylene methylamine/NO (MAHMA/NO)
- PROLI/NO
- Spermine/NO (SPER/NO)
- V-PYRRO/NO
- Heterocyclic compounds: Furoxans: Furoxan
- REC15/2739; Sydnonimines: Feprosidnine
- Linsidomine (SIN-1)
- Molsidomine (SIN-10)
- Sydnonimine
- Unsorted: Cimlanod
- FK-409
- FR144220
- FR146881
- N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
(inhibitors)
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Arginase |
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CAMK |
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- Precursors: L-Arginine
- Nω-Hydroxy-L-arginine (NOHA)
- Indirect/downstream NO modulators: ACE inhibitors/AT-II receptor antagonists (e.g., captopril, losartan)
- ETB receptor antagonists (e.g., bosentan)
- L-Type calcium channel blockers (e.g., dihydropyridines: nifedipine)
- Nebivolol (beta blocker)
- PDE5 inhibitors (e.g., sildenafil)
- non-selective PDE inhibitors (e.g., caffeine)
- PDE9 inhibitors (e.g., paraxanthine)
- cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
- Statins (e.g., simvastatin)