SFRS5

Protein-coding gene in the species Homo sapiens

SRSF5

Identifiers

Aliases

SRSF5, HRS, SFRS5, SRP40, serine/arginine-rich splicing factor 5, serine and arginine rich splicing factor 5

External IDs

OMIM: 600914; MGI: 98287; HomoloGene: 134432; GeneCards: SRSF5; OMA:SRSF5 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q24.1	Start	69,726,900 bp^[1]
Band	14q24.1	End	69,772,005 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 D1	Start	80,992,278 bp^[2]
Band	12\|12 D1	End	80,997,281 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

right hemisphere of cerebellum

anterior pituitary

left lobe of thyroid gland

left ovary

right lobe of thyroid gland

gastric mucosa

Achilles tendon

granulocyte

right ovary

Top expressed in

neural layer of retina

olfactory bulb

ovary

tail of embryo

cerebellum

granulocyte

cerebellar cortex

lens

genital tubercle

lung

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding nucleic acid binding protein kinase B binding RNA binding
Cellular component	nucleoplasm nucleolus nucleus cytosol nuclear speck
Biological process	mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA export from nucleus regulation of cell cycle liver regeneration mRNA splice site selection cellular response to insulin stimulus mRNA 3'-end processing liver development RNA splicing response to insulin RNA export from nucleus positive regulation of RNA splicing regulation of alternative mRNA splicing, via spliceosome mRNA cis splicing, via spliceosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6430


20384

Ensembl


ENSG00000100650


ENSMUSG00000021134

UniProt


Q13243


O35326

RefSeq (mRNA)


NM_001039465 NM_006925 NM_001320214


NM_001079694 NM_001079695 NM_009159 NM_001347415 NM_001347416

RefSeq (protein)


NP_001034554 NP_001307143 NP_008856


NP_001073162 NP_001073163 NP_001334344 NP_001334345 NP_033185

Location (UCSC)

Chr 14: 69.73 – 69.77 Mb

Chr 12: 80.99 – 81 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100650 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021134 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Diamond RH, Du K, Lee VM, Mohn KL, Haber BA, Tewari DS, Taub R (July 1993). "Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing". The Journal of Biological Chemistry. 268 (20): 15185–92. doi:10.1016/S0021-9258(18)82454-1. PMID 7686911.
^ "Entrez Gene: SFRS5 splicing factor, arginine/serine-rich 5".

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Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR (September 1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". The EMBO Journal. 14 (17): 4336–49. doi:10.1002/j.1460-2075.1995.tb00108.x. PMC 394518. PMID 7556075.
Gui JF, Lane WS, Fu XD (June 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-13.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Snow BE, Heng HH, Shi XM, Zhou Y, Du K, Taub R, Tsui LC, McInnes RR (July 1997). "Expression analysis and chromosomal assignment of the human SFRS5/SRp40 gene". Genomics. 43 (2): 165–70. doi:10.1006/geno.1997.4794. PMID 9244433.
Du K, Taub R (December 1997). "Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes". Gene. 204 (1–2): 243–9. doi:10.1016/S0378-1119(97)00552-0. PMID 9434190.
Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
Papoutsopoulou S, Nikolakaki E, Chalepakis G, Kruft V, Chevaillier P, Giannakouros T (July 1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Research. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
Guil S, Gattoni R, Carrascal M, Abián J, Stévenin J, Bach-Elias M (April 2003). "Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation". Molecular and Cellular Biology. 23 (8): 2927–41. doi:10.1128/MCB.23.8.2927-2941.2003. PMC 152554. PMID 12665590.
Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cellular & Developmental Biology. Animal. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC 3225227. PMID 12762840.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
de Graaf K, Hekerman P, Spelten O, Herrmann A, Packman LC, Büssow K, Müller-Newen G, Becker W (February 2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". The Journal of Biological Chemistry. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Ropers D, Ayadi L, Gattoni R, Jacquenet S, Damier L, Branlant C, Stévenin J (July 2004). "Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA". The Journal of Biological Chemistry. 279 (29): 29963–73. doi:10.1074/jbc.M404452200. PMID 15123677.
Caputi M, Freund M, Kammler S, Asang C, Schaal H (June 2004). "A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression". Journal of Virology. 78 (12): 6517–26. doi:10.1128/JVI.78.12.6517-6526.2004. PMC 416506. PMID 15163745.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.