SFRS6

Protein-coding gene in the species Homo sapiens

SRSF6

Identifiers

Aliases

SRSF6, B52, HEL-S-91, SFRS6, SRP55, serine/arginine-rich splicing factor 6, serine and arginine rich splicing factor 6

External IDs

OMIM: 601944; MGI: 1915246; HomoloGene: 110783; GeneCards: SRSF6; OMA:SRSF6 - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q13.11	Start	43,457,893 bp^[1]
Band	20q13.11	End	43,466,046 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 H2\|2 83.87 cM	Start	162,773,448 bp^[2]
Band	2 H2\|2 83.87 cM	End	162,779,041 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

body of pancreas

right lobe of thyroid gland

right adrenal cortex

right ovary

left lobe of thyroid gland

left ovary

germinal epithelium

ventricular zone

left adrenal gland

Top expressed in

medullary collecting duct

abdominal wall

renal corpuscle

endocardial cushion

somite

superior cervical ganglion

epiblast

ventricular zone

dermis

Gonadal ridge

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding RNA binding nucleic acid binding pre-mRNA binding
Cellular component	nuclear speck nucleus nucleoplasm
Biological process	mRNA splicing, via spliceosome termination of RNA polymerase II transcription negative regulation of keratinocyte differentiation positive regulation of epithelial cell proliferation involved in lung morphogenesis mRNA processing negative regulation of cell death regulation of alternative mRNA splicing, via spliceosome mRNA export from nucleus negative regulation of mRNA splicing, via spliceosome regulation of wound healing mRNA splice site selection regulation of keratinocyte proliferation alternative mRNA splicing, via spliceosome mRNA 3'-end processing negative regulation of gene expression RNA splicing response to insulin RNA export from nucleus negative regulation of type B pancreatic cell apoptotic process mRNA cis splicing, via spliceosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6431


67996

Ensembl


ENSG00000124193


ENSMUSG00000016921

UniProt


Q13247


Q3TWW8

RefSeq (mRNA)


NM_006275


NM_026499

RefSeq (protein)


NP_006266


NP_080775

Location (UCSC)

Chr 20: 43.46 – 43.47 Mb

Chr 2: 162.77 – 162.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.^[5]^[6]

Function

The protein encoded by this gene is involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124193 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016921 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR (September 1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". The EMBO Journal. 14 (17): 4336–49. doi:10.1002/j.1460-2075.1995.tb00108.x. PMC 394518. PMID 7556075.
^ ^a ^b "Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6".

Zahler AM, Lane WS, Stolk JA, Roth MB (May 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes & Development. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
Ramchatesingh J, Zahler AM, Neugebauer KM, Roth MB, Cooper TA (September 1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Molecular and Cellular Biology. 15 (9): 4898–907. doi:10.1128/MCB.15.9.4898. PMC 230736. PMID 7651409.
Gui JF, Lane WS, Fu XD (June 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-11.
Nagel RJ, Lancaster AM, Zahler AM (January 1998). "Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55". RNA. 4 (1): 11–23. PMC 1369592. PMID 9436904.
Liu HX, Zhang M, Krainer AR (July 1998). "Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins". Genes & Development. 12 (13): 1998–2012. doi:10.1101/gad.12.13.1998. PMC 316967. PMID 9649504.
Lemaire R, Winne A, Sarkissian M, Lafyatis R (March 1999). "SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation". European Journal of Immunology. 29 (3): 823–37. doi:10.1002/(SICI)1521-4141(199903)29:03<823::AID-IMMU823>3.0.CO;2-C. PMID 10092085. S2CID 23297953.
Paillard F (May 1999). "A novel soluble chimera for the treatment of familial hypercholesterolemia". Human Gene Therapy. 10 (7): 1093–4. doi:10.1089/10430349950018085. PMID 10340541.
Barnard DC, Patton JG (May 2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Molecular and Cellular Biology. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.
Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM (August 2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Molecular Cell. 6 (2): 307–16. doi:10.1016/S1097-2765(00)00031-9. PMID 10983978.
Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW (August 2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Tran Q, Coleman TP, Roesser JR (January 2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1625 (2): 141–52. doi:10.1016/S0167-4781(02)00600-0. PMID 12531473.
Tran Q, Roesser JR (February 2003). "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing". Biochemistry. 42 (4): 951–7. doi:10.1021/bi026753a. PMID 12549914.
Lai MC, Lin RI, Tarn WY (May 2003). "Differential effects of hyperphosphorylation on splicing factor SRp55". The Biochemical Journal. 371 (Pt 3): 937–45. doi:10.1042/BJ20021827. PMC 1223332. PMID 12549978.
Pind MT, Watson PH (May 2003). "SR protein expression and CD44 splicing pattern in human breast tumours". Breast Cancer Research and Treatment. 79 (1): 75–82. doi:10.1023/A:1023338718974. PMID 12779084. S2CID 24657578.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.