SKIV2L2

Protein-coding gene in the species Homo sapiens
MTREX
Identifiers
AliasesMTREX, Dob1, KIAA0052, Mtr4, fSAP118, Ski2 like RNA helicase 2, Mtr4 exosome RNA helicase, SKIV2L2
External IDsOMIM: 618122; MGI: 1919448; HomoloGene: 6257; GeneCards: MTREX; OMA:MTREX - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MTREX
Genomic location for MTREX
Band5q11.2Start55,307,989 bp[1]
End55,425,579 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for MTREX
Genomic location for MTREX
Band13|13 D2.2Start113,003,952 bp[2]
End113,063,932 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • sural nerve

  • gonad

  • epithelium of colon

  • ventricular zone

  • testicle

  • ganglionic eminence

  • jejunal mucosa

  • Skeletal muscle tissue of rectus abdominis

  • islet of Langerhans
Top expressed in
  • primitive streak

  • genital tubercle

  • masseter muscle

  • ureter

  • otic vesicle

  • tail of embryo

  • Paneth cell

  • otic placode

  • facial motor nucleus

  • saccule
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA helicase activity
  • nucleotide binding
  • protein binding
  • ATP binding
  • hydrolase activity
  • helicase activity
  • nucleic acid binding
  • RNA binding
Cellular component
  • catalytic step 2 spliceosome
  • spliceosomal complex
  • nucleolus
  • exosome (RNase complex)
  • nucleus
  • nucleoplasm
  • nuclear exosome (RNase complex)
  • TRAMP complex
Biological process
  • mRNA processing
  • maturation of 5.8S rRNA
  • RNA splicing
  • rRNA processing
  • mRNA splicing, via spliceosome
  • RNA catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23517

72198

Ensembl

ENSG00000039123

ENSMUSG00000016018

UniProt

P42285

Q9CZU3

RefSeq (mRNA)

NM_015360

NM_028151

RefSeq (protein)

NP_056175

NP_082427

Location (UCSC)Chr 5: 55.31 – 55.43 MbChr 13: 113 – 113.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Superkiller viralicidic activity 2-like 2 is a protein that in humans is encoded by the SKIV2L2 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000039123 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016018 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)".

Further reading

  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  • Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. hdl:2066/186951. PMID 11110791.
  • Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. hdl:2066/261980. PMID 11812149.
  • Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  • Lin Z, Crockett DK, Lim MS, Elenitoba-Johnson KS (2004). "High-throughput analysis of protein/peptide complexes by immunoprecipitation and automated LC-MS/MS". J Biomol Tech. 14 (2): 149–55. PMC 2279905. PMID 14676314.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Nagahama M, Yamazoe T, Hara Y, et al. (2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1". Biochem. Biophys. Res. Commun. 346 (3): 1075–82. doi:10.1016/j.bbrc.2006.06.017. PMID 16782053.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Schilders G, van Dijk E, Pruijn GJ (2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res. 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMC 1885644. PMID 17412707.
  • Yang CT, Hindes AE, Hultman KA, Johnson SL (2007). "Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish". PLOS Genet. 3 (6): e88. doi:10.1371/journal.pgen.0030088. PMC 1885281. PMID 17542649.


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