SMU1

Protein-coding gene in the species Homo sapiens

SMU1
Identifiers
AliasesSMU1, BWD, SMU-1, fSAP57, smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans), DNA replication regulator and spliceosomal factor, DNA replication regulator and spliceosomal factor, SMU1 DNA replication regulator and spliceosomal factor
External IDsOMIM: 617811; MGI: 1915546; HomoloGene: 10079; GeneCards: SMU1; OMA:SMU1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for SMU1
Genomic location for SMU1
Band9p21.1Start33,041,765 bp[1]
End33,076,674 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SMU1
Genomic location for SMU1
Band4|4 A5Start40,736,542 bp[2]
End40,757,923 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • internal globus pallidus

  • tendon

  • Achilles tendon

  • tendon of biceps brachii

  • islet of Langerhans

  • white blood cell

  • monocyte

  • ventricular zone

  • Brodmann area 23

  • corpus callosum
Top expressed in
  • spermatocyte

  • secondary oocyte

  • spermatid

  • medial ganglionic eminence

  • primitive streak

  • primary oocyte

  • maxillary prominence

  • mandibular prominence

  • zygote

  • abdominal wall
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • nuclear speck
  • nucleus
  • U2-type precatalytic spliceosome
Biological process
  • regulation of alternative mRNA splicing, via spliceosome
  • mRNA processing
  • RNA splicing
  • mRNA splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55234

74255

Ensembl

ENSG00000122692

ENSMUSG00000028409

UniProt

Q2TAY7

Q3UKJ7

RefSeq (mRNA)

NM_018225

NM_021535

RefSeq (protein)

NP_060695
NP_060695.2

NP_067510

Location (UCSC)Chr 9: 33.04 – 33.08 MbChr 4: 40.74 – 40.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD40 repeat-containing protein SMU1 is a protein that in humans is encoded by the SMU1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122692 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028409 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Spike CA, Shaw JE, Herman RK (Jul 2001). "Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans". Mol Cell Biol. 21 (15): 4985–95. doi:10.1128/MCB.21.15.4985-4995.2001. PMC 87225. PMID 11438655.
  6. ^ Di Benedetto AJ, Klick Stoddard J, Glavan BJ (Jun 2001). "Cloning and molecular characterization of a novel gene encoding a WD-repeat protein expressed in restricted areas of adult rat brain". Gene. 271 (1): 21–31. doi:10.1016/S0378-1119(01)00483-8. PMID 11410362.
  7. ^ "Entrez Gene: SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ficarro SB, Salomon AR, Brill LM, et al. (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Commun. Mass Spectrom. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.
  • Higa LA, Wu M, Ye T, et al. (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl:10397/34293. PMID 17041588. S2CID 22180568.


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