SULT1C3

Protein-coding gene in the species Homo sapiens

SULT1C3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2H8K, 2REO

Identifiers
AliasesSULT1C3, ST1C3, sulfotransferase family 1C member 3
External IDsOMIM: 617151; MGI: 102928; HomoloGene: 56817; GeneCards: SULT1C3; OMA:SULT1C3 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SULT1C3
Genomic location for SULT1C3
Band2q12.3Start108,239,968 bp[1]
End108,265,351 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for SULT1C3
Genomic location for SULT1C3
Band17 C|17 28.07 cMStart54,268,643 bp[2]
End54,297,702 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • duodenum

  • mucosa of transverse colon

  • rectum

  • gastric mucosa

  • body of stomach

  • mucosa of esophagus

  • kidney

  • prostate

  • human kidney
Top expressed in
  • olfactory epithelium

  • retinal pigment epithelium

  • trachea

  • conjunctival fornix

  • zygote

  • secondary oocyte

  • submandibular gland

  • primary oocyte

  • sexually immature organism

  • hippocampal formation
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • alcohol sulfotransferase activity
  • aryl sulfotransferase activity
  • sulfotransferase activity
  • transferase activity
Cellular component
  • cytoplasm
Biological process
  • sulfur compound metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

442038

20888

Ensembl

ENSG00000196228

ENSMUSG00000023943

UniProt

Q6IMI6

Q80VR3

RefSeq (mRNA)

NM_001008743
NM_001320878

NM_018751

RefSeq (protein)

NP_001008743
NP_001307807

NP_061221

Location (UCSC)Chr 2: 108.24 – 108.27 MbChr 17: 54.27 – 54.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the SULT1C3 gene.[5][6][7]

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.[5]

Clinical significance

ST1C3 sulfates large benzylic alcohols such as 1-hydroxymethyl-pyrene to chemically reactive mutagenic sulpho conjugates.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196228 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023943 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: sulfotransferase family".
  6. ^ Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM (2004). "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes". Pharmacogenomics J. 4 (1): 54–65. doi:10.1038/sj.tpj.6500223. PMID 14676822. S2CID 17481502.
  7. ^ Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH (May 2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.
  8. ^ Meinl W, Donath C, Schneider H, Sommer Y, Glatt H (April 2008). "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens". Food Chem. Toxicol. 46 (4): 1249–56. doi:10.1016/j.fct.2007.08.040. PMID 17936463.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Sulfotransferase 1C3 (SULT1C3)


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