SYNJ2BP

Protein-coding gene in the species Homo sapiens
SYNJ2BP
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2ENO, 2JIK, 2JIN

Identifiers
AliasesSYNJ2BP, ARIP2, OMP25, synaptojanin 2 binding protein
External IDsOMIM: 609411; MGI: 1344347; HomoloGene: 10161; GeneCards: SYNJ2BP; OMA:SYNJ2BP - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SYNJ2BP
Genomic location for SYNJ2BP
Band14q24.2Start70,366,499 bp[1]
End70,417,090 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for SYNJ2BP
Genomic location for SYNJ2BP
Band12 D1|12 37.73 cMStart81,544,715 bp[2]
End81,579,685 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • cardia

  • body of tongue

  • pylorus

  • saphenous vein

  • biceps brachii

  • jejunum

  • vena cava

  • Skeletal muscle tissue of biceps brachii

  • Skeletal muscle tissue of rectus abdominis
Top expressed in
  • tunica media of zone of aorta

  • intercostal muscle

  • digastric muscle

  • sternocleidomastoid muscle

  • temporal muscle

  • ciliary body

  • triceps brachii muscle

  • saccule

  • otic placode

  • epithelium of stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • protein C-terminus binding
  • ionotropic glutamate receptor binding
Cellular component
  • integral component of membrane
  • mitochondrial outer membrane
  • membrane
  • mitochondrion
  • integral component of mitochondrial outer membrane
  • ionotropic glutamate receptor complex
  • basolateral plasma membrane
  • cell junction
  • neuromuscular junction
  • neuron projection
  • postsynaptic density membrane
Biological process
  • negative regulation of endothelial cell migration
  • negative regulation of angiogenesis
  • regulation of Notch signaling pathway
  • negative regulation of endothelial cell proliferation
  • negative regulation of sprouting angiogenesis
  • negative regulation of ERK1 and ERK2 cascade
  • protein targeting
  • Rho protein signal transduction
  • regulation of endocytosis
  • intracellular distribution of mitochondria
  • chemical synaptic transmission
  • receptor clustering
  • establishment or maintenance of epithelial cell apical/basal polarity
  • receptor localization to synapse
  • cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55333

24071

Ensembl

ENSG00000213463

ENSMUSG00000090935

UniProt

P57105

Q9D6K5

RefSeq (mRNA)

NM_018373

NM_025292
NM_001309814

RefSeq (protein)

NP_060843

NP_001296743
NP_079568

Location (UCSC)Chr 14: 70.37 – 70.42 MbChr 12: 81.54 – 81.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptojanin-2-binding protein is a protein that in humans is encoded by the SYNJ2BP gene.[5][6]

Interactions

SYNJ2BP has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213463 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090935 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". The Journal of Biological Chemistry. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
  6. ^ "Entrez Gene: SYNJ2BP synaptojanin 2 binding protein".
  7. ^ Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561. S2CID 34666659.
  8. ^ a b Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.

Further reading

  • Nemoto Y, De Camilli P (Jun 1999). "Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein". The EMBO Journal. 18 (11): 2991–3006. doi:10.1093/emboj/18.11.2991. PMC 1171381. PMID 10357812.
  • Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
  • Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P (Oct 2001). "Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein". The Journal of Cell Biology. 155 (3): 393–404. doi:10.1083/jcb.200012039. PMC 2150840. PMID 11673475.
  • Lin F, Yu YP, Woods J, Cieply K, Gooding B, Finkelstein P, Dhir R, Krill D, Becich MJ, Michalopoulos G, Finkelstein S, Luo JH (Nov 2001). "Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers". The American Journal of Pathology. 159 (5): 1603–12. doi:10.1016/S0002-9440(10)63006-4. PMC 3277320. PMID 11696420.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561. S2CID 34666659.


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