TAF1B

Protein-coding gene in the species Homo sapiens
TAF1B
Identifiers
AliasesTAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63, TATA-box binding protein associated factor, RNA polymerase I subunit B
External IDsOMIM: 604904; MGI: 109577; HomoloGene: 31331; GeneCards: TAF1B; OMA:TAF1B - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for TAF1B
Genomic location for TAF1B
Band2p25.1Start9,843,443 bp[1]
End9,934,416 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for TAF1B
Genomic location for TAF1B
Band12|12 A1.3Start24,548,358 bp[2]
End24,608,538 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • Achilles tendon

  • buccal mucosa cell

  • ventricular zone

  • monocyte

  • islet of Langerhans

  • stromal cell of endometrium

  • secondary oocyte

  • olfactory zone of nasal mucosa
Top expressed in
  • spermatocyte

  • zygote

  • secondary oocyte

  • seminiferous tubule

  • yolk sac

  • tail of embryo

  • dentate gyrus of hippocampal formation granule cell

  • morula

  • morula

  • genital tubercle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • DNA-binding transcription factor activity
  • metal ion binding
  • protein binding
  • TBP-class protein binding
  • RNA polymerase I core promoter sequence-specific DNA binding
Cellular component
  • nucleoplasm
  • RNA polymerase transcription factor SL1 complex
  • nucleolus
  • nucleus
  • RNA polymerase I core factor complex
Biological process
  • termination of RNA polymerase I transcription
  • epigenetic maintenance of chromatin in transcription-competent conformation
  • regulation of transcription, DNA-templated
  • transcription initiation from RNA polymerase I promoter
  • transcription, DNA-templated
  • transcription by RNA polymerase I
  • RNA polymerase I preinitiation complex assembly
  • nucleolar large rRNA transcription by RNA polymerase I
  • transcription elongation from RNA polymerase I promoter
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9014

21340

Ensembl

ENSG00000115750

ENSMUSG00000059669

UniProt

Q53T94

P97358

RefSeq (mRNA)

NM_005680
NM_001318976
NM_001318977

NM_020614

RefSeq (protein)

NP_001305905
NP_001305906
NP_005671

NP_065639

Location (UCSC)Chr 2: 9.84 – 9.93 MbChr 12: 24.55 – 24.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.[5][6]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.[6]

Interactions

TAF1B has been shown to interact with RRN3.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115750 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059669 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (January 1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID 7801123.
  6. ^ a b "Entrez Gene: TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa".
  7. ^ Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (March 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.

Further reading

  • Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID 10894955. S2CID 27014629.
  • Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.
  • Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
  • Kim NG, Rhee H, Li LS, Kim H, Lee JS, Kim JH, Kim NK, Kim H (2002). "Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability". Oncogene. 21 (33): 5081–7. doi:10.1038/sj.onc.1205703. PMID 12140758.
  • Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
  • Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054. S2CID 8913931.
  • You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H (2007). "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors". PLOS Biol. 5 (5): e109. doi:10.1371/journal.pbio.0050109. PMC 1854916. PMID 17456004.


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