TCEAL1

Protein-coding gene in the species Homo sapiens
TCEAL1
Identifiers
AliasesTCEAL1, SIIR, WEX9, p21, pp21, transcription elongation factor A like 1
External IDsOMIM: 300237; MGI: 2385317; HomoloGene: 3510; GeneCards: TCEAL1; OMA:TCEAL1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for TCEAL1
Genomic location for TCEAL1
BandXq22.2Start103,628,704 bp[1]
End103,630,953 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for TCEAL1
Genomic location for TCEAL1
BandX|X F1Start135,608,731 bp[2]
End135,612,227 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right ovary

  • left ovary

  • left uterine tube

  • body of uterus

  • gastric mucosa

  • right coronary artery

  • canal of the cervix

  • thoracic aorta

  • Descending thoracic aorta

  • ascending aorta
Top expressed in
  • dorsomedial hypothalamic nucleus

  • facial motor nucleus

  • mammillary body

  • arcuate nucleus

  • paraventricular nucleus of hypothalamus

  • median eminence

  • ventromedial nucleus

  • Region I of hippocampus proper

  • barrel cortex

  • lateral hypothalamus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • WW domain binding
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9338

237052

Ensembl

ENSG00000172465

ENSMUSG00000049536

UniProt

Q15170

Q921P9

RefSeq (mRNA)

NM_004780
NM_001006639
NM_001006640

NM_146236
NM_001356367

RefSeq (protein)

NP_001006640
NP_001006641
NP_004771

NP_666348
NP_001343296

Location (UCSC)Chr X: 103.63 – 103.63 MbChr X: 135.61 – 135.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.[5][6][7]

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172465 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049536 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yeh CH, Shatkin AJ (Jul 1994). "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII". Gene. 143 (2): 285–7. doi:10.1016/0378-1119(94)90112-0. PMID 8206389.
  6. ^ Yeh CH, Shatkin AJ (Dec 1994). "Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein". Proc Natl Acad Sci U S A. 91 (23): 11002–6. Bibcode:1994PNAS...9111002Y. doi:10.1073/pnas.91.23.11002. PMC 45154. PMID 7971997.
  7. ^ a b "Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1".

Further reading

  • Yeh CH, Zong WX, Shatkin AJ (1995). "The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression". J. Biol. Chem. 270 (43): 25313–5. doi:10.1074/jbc.270.44.26558. PMID 7592688.
  • Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR". Genomics. 56 (2): 217–20. doi:10.1006/geno.1998.5705. PMID 10051408.
  • van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. doi:10.1007/s001090050365. PMID 10353443. S2CID 22183443.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Makino H, Tajiri T, Miyashita M, et al. (2005). "Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis". Diseases of the Esophagus. 18 (1): 37–40. doi:10.1111/j.1442-2050.2005.00432.x. PMID 15773840.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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