TMBIM6 |
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Identifiers |
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Aliases | TMBIM6, BAXI1, BI-1, TEGT, transmembrane BAX inhibitor motif containing 6 |
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External IDs | OMIM: 600748; MGI: 99682; HomoloGene: 2419; GeneCards: TMBIM6; OMA:TMBIM6 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12q13.12 | Start | 49,707,725 bp[1] |
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End | 49,764,934 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 15 (mouse)[2] |
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| Band | 15 F1|15 56.13 cM | Start | 99,290,763 bp[2] |
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End | 99,307,930 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - islet of Langerhans
- renal medulla
- parotid gland
- right testis
- left testis
- ventricular zone
- gallbladder
- mucosa of ileum
- rectum
- right adrenal cortex
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| Top expressed in | - lacrimal gland
- vestibular membrane of cochlear duct
- human kidney
- submandibular gland
- olfactory epithelium
- granulocyte
- epithelium of stomach
- parotid gland
- jejunum
- intestinal villus
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - endoribonuclease inhibitor activity
- protein binding
- enzyme binding
- ubiquitin protein ligase binding
| Cellular component | - cytoplasm
- integral component of membrane
- endoplasmic reticulum membrane
- membrane
- mitochondrial membranes
- integral component of plasma membrane
- endoplasmic reticulum
- nucleus
| Biological process | - negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- negative regulation of endoribonuclease activity
- negative regulation of apoptotic signaling pathway
- negative regulation of apoptotic process
- negative regulation of protein binding
- endoplasmic reticulum calcium ion homeostasis
- response to endoplasmic reticulum stress
- autophagy
- response to unfolded protein
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- response to L-glutamate
- negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
- negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
- apoptotic process
- negative regulation of calcium ion transport into cytosol
- negative regulation of RNA splicing
- Unfolded Protein Response
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001171034 NM_001171035 NM_001171036 NM_026669 |
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RefSeq (protein) | | |
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NP_001164505 NP_001164506 NP_001164507 NP_080945 |
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Location (UCSC) | Chr 12: 49.71 – 49.76 Mb | Chr 15: 99.29 – 99.31 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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