TEGT

Protein-coding gene in the species Homo sapiens
TMBIM6
Identifiers
AliasesTMBIM6, BAXI1, BI-1, TEGT, transmembrane BAX inhibitor motif containing 6
External IDsOMIM: 600748; MGI: 99682; HomoloGene: 2419; GeneCards: TMBIM6; OMA:TMBIM6 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TMBIM6
Genomic location for TMBIM6
Band12q13.12Start49,707,725 bp[1]
End49,764,934 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for TMBIM6
Genomic location for TMBIM6
Band15 F1|15 56.13 cMStart99,290,763 bp[2]
End99,307,930 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • renal medulla

  • parotid gland

  • right testis

  • left testis

  • ventricular zone

  • gallbladder

  • mucosa of ileum

  • rectum

  • right adrenal cortex
Top expressed in
  • lacrimal gland

  • vestibular membrane of cochlear duct

  • human kidney

  • submandibular gland

  • olfactory epithelium

  • granulocyte

  • epithelium of stomach

  • parotid gland

  • jejunum

  • intestinal villus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • endoribonuclease inhibitor activity
  • protein binding
  • enzyme binding
  • ubiquitin protein ligase binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • mitochondrial membranes
  • integral component of plasma membrane
  • endoplasmic reticulum
  • nucleus
Biological process
  • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
  • negative regulation of endoribonuclease activity
  • negative regulation of apoptotic signaling pathway
  • negative regulation of apoptotic process
  • negative regulation of protein binding
  • endoplasmic reticulum calcium ion homeostasis
  • response to endoplasmic reticulum stress
  • autophagy
  • response to unfolded protein
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  • response to L-glutamate
  • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
  • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
  • apoptotic process
  • negative regulation of calcium ion transport into cytosol
  • negative regulation of RNA splicing
  • Unfolded Protein Response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7009

110213

Ensembl

ENSG00000139644

ENSMUSG00000023010

UniProt

P55061

Q9D2C7

RefSeq (mRNA)

NM_001098576
NM_003217

NM_001171034
NM_001171035
NM_001171036
NM_026669

RefSeq (protein)

NP_001092046
NP_003208

NP_001164505
NP_001164506
NP_001164507
NP_080945

Location (UCSC)Chr 12: 49.71 – 49.76 MbChr 15: 99.29 – 99.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139644 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023010 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics. 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID 8530040.
  6. ^ Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell. 1 (3): 337–46. doi:10.1016/S1097-2765(00)80034-9. PMID 9660918.
  7. ^ "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Cowling RT, Birnboim HC (1999). "Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT)". Mol. Membr. Biol. 15 (4): 177–87. doi:10.3109/09687689709044319. PMID 10087504.
  • Jean JC, Oakes SM, Joyce-Brady M (1999). "The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters". Genomics. 57 (2): 201–8. doi:10.1006/geno.1999.5761. PMID 10198159.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Grzmil M, Thelen P, Hemmerlein B, et al. (2003). "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells". Am. J. Pathol. 163 (2): 543–52. doi:10.1016/S0002-9440(10)63682-6. PMC 1868227. PMID 12875974.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Tanaka R, Ishiyama T, Uchihara T, et al. (2006). "Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma". Cancer. 106 (3): 648–53. doi:10.1002/cncr.21639. PMID 16353209. S2CID 1629852.
  • Lee GH, Kim HK, Chae SW, et al. (2007). "Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression". J. Biol. Chem. 282 (30): 21618–28. doi:10.1074/jbc.M700053200. PMID 17526500.


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