TRA2A

Protein-coding gene in the species Homo sapiens
TRA2A
Identifiers
AliasesTRA2A, AWMS1, HSU53209, transformer 2 alpha homolog
External IDsOMIM: 602718; MGI: 1933972; HomoloGene: 40866; GeneCards: TRA2A; OMA:TRA2A - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for TRA2A
Genomic location for TRA2A
Band7p15.3Start23,504,780 bp[1]
End23,532,041 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for TRA2A
Genomic location for TRA2A
Band6|6 B2.3Start49,220,858 bp[2]
End49,240,967 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • buccal mucosa cell

  • right ovary

  • ganglionic eminence

  • left ovary

  • ventricular zone

  • canal of the cervix

  • sural nerve

  • body of uterus

  • right lobe of thyroid gland
Top expressed in
  • pineal gland

  • Gonadal ridge

  • abdominal wall

  • maxillary prominence

  • mandibular prominence

  • tail of embryo

  • dermis

  • superior cervical ganglion

  • epiblast

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleic acid binding
  • RNA binding
Cellular component
  • nucleolus
  • intracellular membrane-bounded organelle
  • nucleus
  • ribonucleoprotein complex
Biological process
  • mRNA splicing, via spliceosome
  • mRNA processing
  • RNA splicing
  • positive regulation of mRNA splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29896

101214

Ensembl

ENSG00000164548

ENSMUSG00000029817

UniProt

Q13595

Q6PFR5

RefSeq (mRNA)
NM_001282757
NM_001282758
NM_001282759
NM_013293
NM_001362759

NM_001362760
NM_001362761

NM_198102
NM_001347209
NM_001362188

RefSeq (protein)
NP_001269686
NP_001269687
NP_001269688
NP_037425
NP_001349688

NP_001349689
NP_001349690

n/a

Location (UCSC)Chr 7: 23.5 – 23.53 MbChr 6: 49.22 – 49.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.[5][6][7]

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164548 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029817 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dauwalder B, Amaya-Manzanares F, Mattox W (Oct 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proc Natl Acad Sci U S A. 93 (17): 9004–9. Bibcode:1996PNAS...93.9004D. doi:10.1073/pnas.93.17.9004. PMC 38585. PMID 8799144.
  6. ^ Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.
  7. ^ a b "Entrez Gene: TRA2A transformer-2 alpha".

Further reading

  • Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
  • Shin C, Feng Y, Manley JL (2004). "Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock". Nature. 427 (6974): 553–8. Bibcode:2004Natur.427..553S. doi:10.1038/nature02288. PMID 14765198. S2CID 4423246.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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