TIE1 |
---|
|
Identifiers |
---|
Aliases | TIE1, JTK14, TIE, tyrosine kinase with immunoglobulin like and EGF like domains 1, LMPHM11 |
---|
External IDs | OMIM: 600222; MGI: 99906; HomoloGene: 3957; GeneCards: TIE1; OMA:TIE1 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 1 (human)[1] |
---|
| Band | 1p34.2 | Start | 43,300,982 bp[1] |
---|
End | 43,323,108 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 4 (mouse)[2] |
---|
| Band | 4 D2.1|4 54.67 cM | Start | 118,328,388 bp[2] |
---|
End | 118,347,258 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - apex of heart
- right lung
- upper lobe of left lung
- right lobe of thyroid gland
- subcutaneous adipose tissue
- left lobe of thyroid gland
- body of uterus
- left ventricle
- right auricle
- tibial nerve
|
| Top expressed in | - cardiac muscle tissue of left ventricle
- left lung
- ankle joint
- right lung
- interventricular septum
- left lung lobe
- right lung lobe
- yolk sac
- atrium
- vein
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - transferase activity
- nucleotide binding
- protein kinase activity
- kinase activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- protein tyrosine kinase activity
- ATP binding
- receptor tyrosine kinase
- transmembrane signaling receptor activity
| Cellular component | - integral component of membrane
- membrane
- plasma membrane
- integral component of plasma membrane
- cytoplasm
- receptor complex
| Biological process | - plasma membrane fusion
- response to retinoic acid
- phosphorylation
- in utero embryonic development
- vasculogenesis
- protein phosphorylation
- negative regulation of cell migration
- blood vessel development
- angiogenesis
- negative regulation of angiogenesis
- mesoderm development
- signal transduction
- peptidyl-tyrosine phosphorylation
- negative regulation of signal transduction
- cell differentiation
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of angiogenesis
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 1: 43.3 – 43.32 Mb | Chr 4: 118.33 – 118.35 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|