Protein-coding gene in the species Homo sapiens
UQCRC1 |
---|
|
Identifiers |
---|
Aliases | UQCRC1, D3S3191, QCR1, UQCR1, ubiquinol-cytochrome c reductase core protein I, ubiquinol-cytochrome c reductase core protein 1, PKNPY |
---|
External IDs | OMIM: 191328; MGI: 107876; HomoloGene: 2525; GeneCards: UQCRC1; OMA:UQCRC1 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 3 (human)[1] |
---|
| Band | 3p21.31 | Start | 48,599,002 bp[1] |
---|
End | 48,610,976 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 9 (mouse)[2] |
---|
| Band | 9 F2|9 59.63 cM | Start | 108,765,701 bp[2] |
---|
End | 108,778,691 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - apex of heart
- left ventricle
- right ventricle
- triceps brachii muscle
- myocardium of left ventricle
- gastrocnemius muscle
- muscle of thigh
- mucosa of transverse colon
- right auricle
- vastus lateralis muscle
|
| Top expressed in | - proximal tubule
- heart
- right kidney
- muscle tissue
- muscle of thigh
- skeletal muscle tissue
- quadriceps femoris muscle
- human kidney
- neural layer of retina
- duodenum
|
| More reference expression data |
|
---|
BioGPS | | More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - ubiquinol-cytochrome-c reductase activity
- protein-containing complex binding
- zinc ion binding
- metal ion binding
- catalytic activity
- metalloendopeptidase activity
- ubiquitin protein ligase binding
| Cellular component | - mitochondrial respiratory chain complex III
- membrane
- myelin sheath
- mitochondrion
- mitochondrial respirasome
- mitochondrial inner membrane
- respirasome
- cytosol
| Biological process | - protein processing
- response to activity
- aerobic respiration
- oxidative phosphorylation
- response to alkaloid
- mitochondrial electron transport, ubiquinol to cytochrome c
- proton transmembrane transport
- proteolysis
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 3: 48.6 – 48.61 Mb | Chr 9: 108.77 – 108.78 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.[5][6]
Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000010256 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025651 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS (Nov 1993). "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase". J Biol Chem. 268 (28): 21113–9. doi:10.1016/S0021-9258(19)36900-5. PMID 8407948.
- ^ "Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I".
Further reading
- Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1991). "Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system". J. Biol. Chem. 266 (4): 2333–8. doi:10.1016/S0021-9258(18)52248-1. PMID 1846623.
- Broger C, Nałecz MJ, Azzi A (1980). "Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain". Biochim. Biophys. Acta. 592 (3): 519–27. doi:10.1016/0005-2728(80)90096-1. PMID 6251869.
- Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (2): 410. PMID 7951059.
- Islam MM, Tanaka M, Suzuki H, et al. (1995). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (4): 815. PMID 7981668.
- Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 32 (5): 797–805. PMID 8069229.
- Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870. S2CID 33424554.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency". Hum. Genet. 104 (6): 460–6. doi:10.1007/s004390050988. PMID 10453733. S2CID 30584267.
- Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP)". J. Neurochem. 81 (1): 36–45. doi:10.1046/j.1471-4159.2002.00788.x. PMID 12067236. S2CID 38794348.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Kulawiec M, Arnouk H, Desouki MM, et al. (2007). "Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer". Cancer Biol. Ther. 5 (8): 967–75. doi:10.4161/cbt.5.8.2880. PMID 16775426. S2CID 84608368.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
PDB gallery
-
1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE -
1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE -
1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone -
1l0n: native structure of bovine mitochondrial cytochrome bc1 complex -
1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 -
1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom -
1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone -
1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) -
1pp9: Bovine cytochrome bc1 complex with stigmatellin bound -
1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin -
1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY -
1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) -
1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT -
1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A -
2a06: Bovine cytochrome bc1 complex with stigmatellin bound -
2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor |
| This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it. |