USP36

Protein-coding gene in the species Homo sapiens
USP36
Identifiers
AliasesUSP36, DUB1, ubiquitin specific peptidase 36
External IDsOMIM: 612543; MGI: 1919594; HomoloGene: 11828; GeneCards: USP36; OMA:USP36 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for USP36
Genomic location for USP36
Band17q25.3Start78,787,381 bp[1]
End78,841,441 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for USP36
Genomic location for USP36
Band11|11 E2Start118,150,477 bp[2]
End118,181,070 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • anterior pituitary

  • left ovary

  • right ovary

  • left uterine tube

  • body of pancreas

  • right hemisphere of cerebellum

  • skin of leg

  • skin of abdomen

  • gastric mucosa
Top expressed in
  • Rostral migratory stream

  • zygote

  • genital tubercle

  • primitive streak

  • neural layer of retina

  • tail of embryo

  • lacrimal gland

  • muscle of thigh

  • epiblast

  • otic vesicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • thiol-dependent deubiquitinase
  • peptidase activity
  • cysteine-type peptidase activity
  • hydrolase activity
  • RNA binding
Cellular component
  • nucleolus
  • nucleus
  • nuclear speck
Biological process
  • protein deubiquitination
  • regulation of autophagy of mitochondrion
  • ubiquitin-dependent protein catabolic process
  • positive regulation of protein targeting to mitochondrion
  • proteolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57602

72344

Ensembl

ENSG00000055483

ENSMUSG00000033909

UniProt

Q9P275

B1AQJ2

RefSeq (mRNA)

NM_025090
NM_001321291

NM_001033528

RefSeq (protein)

NP_001308220

NP_001028700

Location (UCSC)Chr 17: 78.79 – 78.84 MbChr 11: 118.15 – 118.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene. [5] [6]

This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubiquitinate nucleophosmin and fibrillarin[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000055483 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033909 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP36 ubiquitin specific peptidase 36".
  7. ^ Endo A, Matsumoto M, Inada T, Yamamoto A, Nakayama KI, Kitamura N, Komada M (Mar 2009). "Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36". J Cell Sci. 122 (Pt 5): 678–86. doi:10.1242/jcs.044461. PMID 19208757.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–4109. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
  • Kim MS, Yoo KJ, Kang I, et al. (2005). "A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells". Int. J. Oncol. 25 (2): 373–9. doi:10.3892/ijo.25.2.373. PMID 15254734.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Kim MS, Kim YK, Kim YS, et al. (2005). "Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated". Biochem. Biophys. Res. Commun. 330 (3): 797–804. doi:10.1016/j.bbrc.2005.03.051. PMID 15809067.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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