USP42

Protein-coding gene in the species Homo sapiens
USP42
Identifiers
AliasesUSP42, ubiquitin specific peptidase 42
External IDsMGI: 1924050; HomoloGene: 35425; GeneCards: USP42; OMA:USP42 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for USP42
Genomic location for USP42
Band7p22.1Start6,104,949 bp[1]
End6,161,564 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for USP42
Genomic location for USP42
Band5 G2|5 82.5 cMStart143,696,080 bp[2]
End143,718,035 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • pancreatic epithelial cell

  • mucosa of ileum

  • pancreatic ductal cell

  • testicle

  • Brodmann area 23

  • tibialis anterior muscle

  • nipple

  • cartilage tissue

  • postcentral gyrus
Top expressed in
  • cumulus cell

  • vas deferens

  • utricle

  • tail of embryo

  • seminiferous tubule

  • abdominal wall

  • maxillary prominence

  • genital tubercle

  • mandibular prominence

  • foot
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cysteine-type peptidase activity
  • protein binding
  • peptidase activity
  • hydrolase activity
  • thiol-dependent deubiquitinase
  • cysteine-type endopeptidase activity
Cellular component
  • nucleoplasm
Biological process
  • ubiquitin-dependent protein catabolic process
  • spermatogenesis
  • proteolysis
  • cell differentiation
  • protein deubiquitination
  • regulation of apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84132

76800

Ensembl

ENSG00000106346

ENSMUSG00000051306

UniProt

Q9H9J4

B2RQC2

RefSeq (mRNA)

NM_032172
NM_001365764
NM_001389650

NM_029749

RefSeq (protein)

NP_115548
NP_001352693

NP_084025

Location (UCSC)Chr 7: 6.1 – 6.16 MbChr 5: 143.7 – 143.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 42 is an enzyme that in humans is encoded by the USP42 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106346 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051306 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP42 ubiquitin specific peptidase 42".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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