USP6NL

Protein-coding gene in the species Homo sapiens
USP6NL
Identifiers
AliasesUSP6NL, RNTRE, TRE2NL, USP6NL-IT1, USP6 N-terminal like
External IDsOMIM: 605405; MGI: 2138893; HomoloGene: 6879; GeneCards: USP6NL; OMA:USP6NL - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for USP6NL
Genomic location for USP6NL
Band10p14Start11,460,510 bp[1]
End11,611,666 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for USP6NL
Genomic location for USP6NL
Band2|2 A1Start6,327,478 bp[2]
End6,451,201 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amniotic fluid

  • sperm

  • oral cavity

  • epithelium of nasopharynx

  • ventricular zone

  • gums

  • tonsil

  • gingival epithelium

  • palpebral conjunctiva

  • tibia
Top expressed in
  • sciatic nerve

  • otolith organ

  • utricle

  • hand

  • hair follicle

  • retinal pigment epithelium

  • genital tubercle

  • pineal gland

  • tail of embryo

  • conjunctival fornix
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • GTPase activator activity
Cellular component
  • plasma membrane
  • Golgi apparatus
  • cytoplasmic vesicle
  • cytosol
  • endomembrane system
  • trans-Golgi network membrane
Biological process
  • regulation of cilium assembly
  • retrograde transport, plasma membrane to Golgi
  • regulation of Golgi organization
  • Golgi organization
  • plasma membrane to endosome transport
  • activation of GTPase activity
  • regulation of vesicle fusion
  • intracellular protein transport
  • positive regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9712

98910

Ensembl

ENSG00000148429

ENSMUSG00000039046

UniProt

Q92738

Q80XC3

RefSeq (mRNA)

NM_001080491
NM_014688
NM_001391959
NM_001391960
NM_001391961

NM_001080548
NM_181399

RefSeq (protein)

NP_001073960
NP_055503

NP_001074017
NP_852064

Location (UCSC)Chr 10: 11.46 – 11.61 MbChr 2: 6.33 – 6.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

USP6 N-terminal-like protein is a protein that in humans is encoded by the USP6NL gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148429 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039046 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Matòsková B, Wong WT, Seki N, Nagase T, Nomura N, Robbins KC, Di Fiore PP (Jun 1996). "RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain". Oncogene. 12 (12): 2563–71. PMID 8700515.
  6. ^ Matòsková B, Wong WT, Nomura N, Robbins KC, Di Fiore PP (Jun 1996). "RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation". Oncogene. 12 (12): 2679–88. PMID 8700527.
  7. ^ "Entrez Gene: USP6NL USP6 N-terminal like".

Further reading

  • Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  • Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Research. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  • Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (Nov 2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID 11099046. S2CID 4405293.
  • Martinu L, Santiago-Walker A, Qi H, Chou MM (Dec 2002). "Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre". The Journal of Biological Chemistry. 277 (52): 50996–1002. doi:10.1074/jbc.M204869200. PMID 12399475.
  • Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Lanzetti L, Palamidessi A, Areces L, Scita G, Di Fiore PP (May 2004). "Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases". Nature. 429 (6989): 309–14. doi:10.1038/nature02542. PMID 15152255. S2CID 4431181.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Lanzetti L, Margaria V, Melander F, Virgili L, Lee MH, Bartek J, Jensen S (May 2007). "Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells". The Journal of Biological Chemistry. 282 (20): 15258–70. doi:10.1074/jbc.M700914200. PMID 17371873.
  • v
  • t
  • e