Protein-coding gene in the species Homo sapiens
VSIG4 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2ICC, 2ICE, 2ICF |
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Identifiers |
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Aliases | VSIG4, CRIg, Z39IG, V-set and immunoglobulin domain containing 4 |
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External IDs | OMIM: 300353; MGI: 2679720; HomoloGene: 48515; GeneCards: VSIG4; OMA:VSIG4 - orthologs |
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Gene location (Human) |
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![X chromosome (human)](//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/300px-Ideogram_human_chromosome_X.svg.png) | Chr. | X chromosome (human)[1] |
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| Band | Xq12 | Start | 66,021,738 bp[1] |
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End | 66,040,125 bp[1] |
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Gene location (Mouse) |
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![X chromosome (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/260px-Ideogram_house_mouse_chromosome_X.svg.png) | Chr. | X chromosome (mouse)[2] |
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| Band | X|X C3 | Start | 95,290,809 bp[2] |
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End | 95,337,044 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right lung
- lower lobe of lung
- gastric mucosa
- right coronary artery
- right adrenal cortex
- synovial membrane
- upper lobe of lung
- upper lobe of left lung
- synovial joint
- visceral pleura
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| Top expressed in | - stroma of bone marrow
- ankle
- liver
- left lobe of liver
- myocardium of ventricle
- tibiofemoral joint
- granulocyte
- muscle of thigh
- aorta
- skin of external ear
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein binding
- complement component C3b binding
| Cellular component | - integral component of membrane
- membrane
- protein-containing complex
| Biological process | - innate immune response
- complement activation, alternative pathway
- immune system process
- negative regulation of interleukin-2 production
- negative regulation of T cell proliferation
- negative regulation of macrophage activation
- negative regulation of complement activation, alternative pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_007268 NM_001100431 NM_001184830 NM_001184831 NM_001257403 |
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RefSeq (protein) | |
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NP_001093901 NP_001171759 NP_001171760 NP_001244332 NP_009199 |
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Location (UCSC) | Chr X: 66.02 – 66.04 Mb | Chr X: 95.29 – 95.34 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene.[5]
Function
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000155659 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044206 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: V-set and immunoglobulin domain containing 4". Retrieved 2016-06-13.
Further reading
- Helmy KY, Katschke KJ, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.