VSIG1

Protein-coding gene in the species Homo sapiens
VSIG1
Identifiers
AliasesVSIG1, 1700062D20Rik, GPA34, dJ889N15.1, V-set and immunoglobulin domain containing 1
External IDsOMIM: 300620; MGI: 1926039; HomoloGene: 12703; GeneCards: VSIG1; OMA:VSIG1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for VSIG1
Genomic location for VSIG1
BandXq22.3Start108,044,970 bp[1]
End108,079,184 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for VSIG1
Genomic location for VSIG1
BandX|X F1Start139,808,357 bp[2]
End139,840,221 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pylorus

  • right testis

  • left testis

  • pancreatic epithelial cell

  • body of stomach

  • cardia

  • pancreatic ductal cell

  • gallbladder

  • gastric mucosa

  • fundus
Top expressed in
  • testicle

  • stomach

  • spermatid

  • spermatocyte

  • duodenum

  • islet of Langerhans

  • colon

  • right kidney

  • quadriceps femoris muscle
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

340547

78789

Ensembl

ENSG00000101842

ENSMUSG00000031430

UniProt

Q86XK7

Q9D2J4

RefSeq (mRNA)

NM_001170553
NM_182607

NM_026103
NM_030181
NM_001359143

RefSeq (protein)

NP_001164024
NP_872413

NP_080379
NP_084457
NP_001346072

Location (UCSC)Chr X: 108.04 – 108.08 MbChr X: 139.81 – 139.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

V-set and immunoglobulin domain containing 1 is a protein that in humans is encoded by the VSIG1 gene.[5]

Function

This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in a normal stomach and testis, as well as in gastric, esophageal, and ovarian cancers. Alternatively spliced transcript variants, encoding different isoforms, have been found for this gene. [provided by RefSeq, Dec 2009].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101842 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031430 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: V-set and immunoglobulin domain containing 1". Retrieved 2018-09-09.

Further reading

  • Scanlan MJ, Ritter G, Yin BW, Williams C, Cohen LS, Coplan KA, Fortunato SR, Frosina D, Lee SY, Murray AE, Chua R, Filonenko VV, Sato E, Old LJ, Jungbluth AA (January 2006). "Glycoprotein A34, a novel target for antibody-based cancer immunotherapy". Cancer Immun. 6: 2. PMID 16405301.
  • Chen Y, Pan K, Li S, Xia J, Wang W, Chen J, Zhao J, Lü L, Wang D, Pan Q, Wang Q, Li Y, He J, Li Q (September 2012). "Decreased expression of V-set and immunoglobulin domain containing 1 (VSIG1) is associated with poor prognosis in primary gastric cancer" (PDF). J Surg Oncol. 106 (3): 286–93. doi:10.1002/jso.22150. hdl:2027.42/92382. PMID 22095633. S2CID 12675519.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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