WDR26

Protein-coding gene in the species Homo sapiens
WDR26
Identifiers
AliasesWDR26, CDW2, GID7, MIP2, WD repeat domain 26, SKDEAS
External IDsOMIM: 617424; MGI: 1923825; HomoloGene: 11857; GeneCards: WDR26; OMA:WDR26 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for WDR26
Genomic location for WDR26
Band1q42.11-q42.12Start224,385,146 bp[1]
End224,437,033 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for WDR26
Genomic location for WDR26
Band1|1 H4Start181,000,793 bp[2]
End181,039,566 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • secondary oocyte

  • mucosa of pharynx

  • epithelium of colon

  • bone marrow cells

  • stromal cell of endometrium

  • trabecular bone

  • oral cavity

  • skin of thigh

  • amniotic fluid
Top expressed in
  • aortic valve

  • ascending aorta

  • human fetus

  • Rostral migratory stream

  • blood

  • tibiofemoral joint

  • parotid gland

  • left lung lobe

  • skin of external ear

  • epithelium of lens
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80232

226757

Ensembl

ENSG00000162923

ENSMUSG00000038733

UniProt

Q9H7D7

Q8C6G8

RefSeq (mRNA)

NM_001115113
NM_025160
NM_001379403

NM_145514

RefSeq (protein)

NP_001108585
NP_079436
NP_001366332

NP_663489
NP_001390510
NP_001390511
NP_001390512
NP_001390513

NP_001390514
NP_001390515
NP_001390516
NP_001390517
NP_001390518

Location (UCSC)Chr 1: 224.39 – 224.44 MbChr 1: 181 – 181.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.[5]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162923 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038733 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WDR26 WD repeat domain 26".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Higa LA, Wu M, Ye T, et al. (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588. S2CID 22180568.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhu Y, Wang Y, Xia C, et al. (2005). "WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway". J. Cell. Biochem. 93 (3): 579–87. doi:10.1002/jcb.20175. PMID 15378603. S2CID 86601953.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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