Protein-coding gene in the species Homo sapiens
WDR26 |
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Identifiers |
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Aliases | WDR26, CDW2, GID7, MIP2, WD repeat domain 26, SKDEAS |
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External IDs | OMIM: 617424; MGI: 1923825; HomoloGene: 11857; GeneCards: WDR26; OMA:WDR26 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1q42.11-q42.12 | Start | 224,385,146 bp[1] |
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End | 224,437,033 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1|1 H4 | Start | 181,000,793 bp[2] |
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End | 181,039,566 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - sperm
- secondary oocyte
- mucosa of pharynx
- epithelium of colon
- bone marrow cells
- stromal cell of endometrium
- trabecular bone
- oral cavity
- skin of thigh
- amniotic fluid
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| Top expressed in | - aortic valve
- ascending aorta
- human fetus
- Rostral migratory stream
- blood
- tibiofemoral joint
- parotid gland
- left lung lobe
- skin of external ear
- epithelium of lens
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| More reference expression data |
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BioGPS | | More reference expression data |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001115113 NM_025160 NM_001379403 |
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RefSeq (protein) | |
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NP_001108585 NP_079436 NP_001366332 |
| NP_663489 NP_001390510 NP_001390511 NP_001390512 NP_001390513
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NP_001390514 NP_001390515 NP_001390516 NP_001390517 NP_001390518 |
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Location (UCSC) | Chr 1: 224.39 – 224.44 Mb | Chr 1: 181 – 181.04 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.[5]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162923 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038733 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: WDR26 WD repeat domain 26".
Further reading
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Higa LA, Wu M, Ye T, et al. (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588. S2CID 22180568.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zhu Y, Wang Y, Xia C, et al. (2005). "WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway". J. Cell. Biochem. 93 (3): 579–87. doi:10.1002/jcb.20175. PMID 15378603. S2CID 86601953.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.