WDR4

Protein-coding gene in the species Homo sapiens
WDR4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3CKK

Identifiers
AliasesWDR4, TRM82, TRMT82, WD repeat domain 4, GAMOS6, MIGSB, hWH, Wuho
External IDsOMIM: 605924; MGI: 1889002; HomoloGene: 32422; GeneCards: WDR4; OMA:WDR4 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for WDR4
Genomic location for WDR4
Band21q22.3Start42,843,094 bp[1]
End42,879,568 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for WDR4
Genomic location for WDR4
Band17|17 B1Start31,713,296 bp[2]
End31,738,954 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gingival epithelium

  • mucosa of transverse colon

  • gonad

  • gastrocnemius muscle

  • pancreatic ductal cell

  • testicle

  • stromal cell of endometrium

  • body of pancreas

  • vagina

  • ganglionic eminence
Top expressed in
  • epiblast

  • yolk sac

  • embryo

  • embryo

  • ventricular zone

  • primitive streak

  • granulocyte

  • lens

  • morula

  • blastocyst
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • tRNA (guanine-N7-)-methyltransferase activity
  • protein binding
Cellular component
  • nucleoplasm
  • nucleus
  • cytosol
  • tRNA methyltransferase complex
Biological process
  • RNA (guanine-N7)-methylation
  • tRNA modification
  • tRNA processing
  • tRNA (guanine-N7)-methylation
  • tRNA methylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10785

57773

Ensembl

ENSG00000160193

ENSMUSG00000024037

UniProt

P57081

Q9EP82

RefSeq (mRNA)
NM_001260474
NM_001260475
NM_001260476
NM_001260477
NM_018669

NM_033661

NM_021322

RefSeq (protein)
NP_001247403
NP_001247404
NP_001247405
NP_001247406
NP_061139

NP_387510

NP_067297

Location (UCSC)Chr 21: 42.84 – 42.88 MbChr 17: 31.71 – 31.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme subunit that in humans is encoded by the WDR4 gene.[5]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160193 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024037 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WDR4 WD repeat domain 4".

Further reading

  • Michaud J, Kudoh J, Berry A, et al. (2001). "Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein". Genomics. 68 (1): 71–9. doi:10.1006/geno.2000.6258. PMID 10950928.
  • Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA". RNA. 8 (10): 1253–66. doi:10.1017/S1355838202024019. PMC 1370335. PMID 12403464.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells". EMBO J. 24 (9): 1696–705. doi:10.1038/sj.emboj.7600648. PMC 1142581. PMID 15861136.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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