Protein-coding gene in the species Homo sapiens
WDR4 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | WDR4, TRM82, TRMT82, WD repeat domain 4, GAMOS6, MIGSB, hWH, Wuho |
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External IDs | OMIM: 605924; MGI: 1889002; HomoloGene: 32422; GeneCards: WDR4; OMA:WDR4 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 21 (human)[1] |
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| Band | 21q22.3 | Start | 42,843,094 bp[1] |
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End | 42,879,568 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 17 (mouse)[2] |
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| Band | 17|17 B1 | Start | 31,713,296 bp[2] |
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End | 31,738,954 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gingival epithelium
- mucosa of transverse colon
- gonad
- gastrocnemius muscle
- pancreatic ductal cell
- testicle
- stromal cell of endometrium
- body of pancreas
- vagina
- ganglionic eminence
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| Top expressed in | - epiblast
- yolk sac
- embryo
- embryo
- ventricular zone
- primitive streak
- granulocyte
- lens
- morula
- blastocyst
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - tRNA (guanine-N7-)-methyltransferase activity
- protein binding
| Cellular component | - nucleoplasm
- nucleus
- cytosol
- tRNA methyltransferase complex
| Biological process | - RNA (guanine-N7)-methylation
- tRNA modification
- tRNA processing
- tRNA (guanine-N7)-methylation
- tRNA methylation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001260474 NM_001260475 NM_001260476 NM_001260477 NM_018669
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NM_033661 |
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RefSeq (protein) | NP_001247403 NP_001247404 NP_001247405 NP_001247406 NP_061139
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NP_387510 |
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Location (UCSC) | Chr 21: 42.84 – 42.88 Mb | Chr 17: 31.71 – 31.74 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme subunit that in humans is encoded by the WDR4 gene.[5]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.[5]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000160193 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024037 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: WDR4 WD repeat domain 4".
Further reading
- Michaud J, Kudoh J, Berry A, et al. (2001). "Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein". Genomics. 68 (1): 71–9. doi:10.1006/geno.2000.6258. PMID 10950928.
- Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA". RNA. 8 (10): 1253–66. doi:10.1017/S1355838202024019. PMC 1370335. PMID 12403464.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells". EMBO J. 24 (9): 1696–705. doi:10.1038/sj.emboj.7600648. PMC 1142581. PMID 15861136.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.