WDR46

Protein-coding gene in the species Homo sapiens

WDR46
Identifiers
AliasesWDR46, BING4, C6orf11, FP221, UTP7, WD repeat domain 46
External IDsOMIM: 611440; MGI: 1931871; HomoloGene: 3981; GeneCards: WDR46; OMA:WDR46 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for WDR46
Genomic location for WDR46
Band6p21.32Start33,279,108 bp[1]
End33,289,247 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for WDR46
Genomic location for WDR46
Band17|17 B1Start34,159,634 bp[2]
End34,168,671 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • stromal cell of endometrium

  • anterior pituitary

  • mucosa of transverse colon

  • spleen

  • appendix

  • left testis

  • skin of leg

  • apex of heart

  • right lobe of thyroid gland
Top expressed in
  • Gonadal ridge

  • epiblast

  • submandibular gland

  • gastrula

  • abdominal wall

  • hair follicle

  • mandibular prominence

  • Paneth cell

  • primitive streak

  • maxillary prominence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA binding
Cellular component
  • small-subunit processome
  • nucleolus
  • 90S preribosome
  • nucleus
  • nucleoplasm
  • cellular component
Biological process
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • positive regulation of protein targeting to mitochondrion
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9277

57315

Ensembl
ENSG00000206284
ENSG00000236222
ENSG00000204221
ENSG00000226916
ENSG00000227057

n/a

ENSMUSG00000024312

UniProt

O15213

Q9Z0H1

RefSeq (mRNA)

NM_001164267
NM_005452

NM_020603

RefSeq (protein)

NP_001157739
NP_005443

NP_065628

Location (UCSC)Chr 6: 33.28 – 33.29 MbChr 17: 34.16 – 34.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat-containing protein 46 is a protein that in humans is encoded by the WDR46 gene.[5][6][7]


References

  1. ^ a b c ENSG00000236222, ENSG00000204221, ENSG00000226916, ENSG00000227057 GRCh38: Ensembl release 89: ENSG00000206284, ENSG00000236222, ENSG00000204221, ENSG00000226916, ENSG00000227057 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024312 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Herberg JA, Beck S, Trowsdale J (May 1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J Mol Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
  6. ^ Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J (Mar 1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC". Eur J Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053. S2CID 35772444.
  7. ^ "Entrez Gene: WDR46 WD repeat domain 46".

Further reading

  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.


  • v
  • t
  • e