ZBED3

Protein-coding gene in the species Homo sapiens
ZBED3
Identifiers
AliasesZBED3, zinc finger BED-type containing 3
External IDsOMIM: 615250; MGI: 1919364; HomoloGene: 12442; GeneCards: ZBED3; OMA:ZBED3 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ZBED3
Genomic location for ZBED3
Band5q13.3Start77,072,072 bp[1]
End77,087,285 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for ZBED3
Genomic location for ZBED3
Band13|13 D1Start95,460,120 bp[2]
End95,474,349 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • mucosa of ileum

  • retinal pigment epithelium

  • smooth muscle tissue

  • left lobe of thyroid gland

  • subcutaneous adipose tissue

  • right lobe of thyroid gland

  • parotid gland

  • body of uterus

  • body of pancreas
Top expressed in
  • secondary oocyte

  • zygote

  • primary oocyte

  • genital tubercle

  • tail of embryo

  • ventricular zone

  • yolk sac

  • right kidney

  • choroid plexus of fourth ventricle

  • lactiferous gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • metal ion binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • membrane
  • cytosol
Biological process
  • positive regulation of canonical Wnt signaling pathway
  • negative regulation of protein phosphorylation
  • protein stabilization
  • Wnt signaling pathway
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84327

72114

Ensembl

ENSG00000132846

ENSMUSG00000041995

UniProt

Q96IU2

Q9D0L1

RefSeq (mRNA)

NM_032367
NM_001329564

NM_028106
NM_001302538
NM_001302539

RefSeq (protein)

NP_001316493
NP_115743

NP_001289467
NP_001289468
NP_082382

Location (UCSC)Chr 5: 77.07 – 77.09 MbChr 13: 95.46 – 95.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger BED domain-containing protein 3 also known as axin-interacting protein is a protein in humans that is encoded by the ZBED3 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132846 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041995 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger, BED-type containing 3".

Further reading

  • Hayward A, Ghazal A, Andersson G, Andersson L, Jern P (2013). Robinson-Rechavi M (ed.). "ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions". PLOS ONE. 8 (3): e59940. Bibcode:2013PLoSO...859940H. doi:10.1371/journal.pone.0059940. PMC 3606216. PMID 23533661.
  • de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB, Cupples LA, Meigs JB (Jan 2011). "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms" (PDF). Diabetes Care. 34 (1): 121–5. doi:10.2337/dc10-1265. PMC 3005447. PMID 20889853.
  • Chen T, Li M, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L (Mar 2009). "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling". The Journal of Biological Chemistry. 284 (11): 6683–9. doi:10.1074/jbc.M807753200. PMC 2652294. PMID 19141611.
  • Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, et al. (Jul 2010). "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis". Nature Genetics. 42 (7): 579–89. doi:10.1038/ng.609. PMC 3080658. PMID 20581827.


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