Protein-coding gene in the species Homo sapiens
ZNF16 |
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Identifiers |
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Aliases | ZNF16, HZF1, KOX9, zinc finger protein 16 |
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External IDs | OMIM: 601262; HomoloGene: 56008; GeneCards: ZNF16; OMA:ZNF16 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 8 (human)[1] |
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| Band | 8q24.3 | Start | 144,930,358 bp[1] |
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End | 144,950,888 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gonad
- testicle
- oocyte
- ganglionic eminence
- gastrocnemius muscle
- muscle of thigh
- secondary oocyte
- ventricular zone
- skin of leg
- gingival epithelium
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| | More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - DNA-binding transcription factor activity
- DNA binding
- protein binding
- metal ion binding
- nucleic acid binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | | Biological process | - positive regulation of cell cycle phase transition
- positive regulation of kinase activity
- cell cycle
- negative regulation of apoptotic process
- regulation of transcription, DNA-templated
- positive regulation of megakaryocyte differentiation
- positive regulation of cell division
- positive regulation of erythrocyte differentiation
- transcription, DNA-templated
- positive regulation of cell population proliferation
- cellular response to sodium dodecyl sulfate
- cell division
- regulation of transcription by RNA polymerase II
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 8: 144.93 – 144.95 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Zinc finger protein 16 is a protein that in humans is encoded by the ZNF16 gene.[3]
The protein encoded by this gene contains a C2H2 type of zinc finger, and thus may function as a transcription factor. This gene is located in a region close to ZNF7/KOX4, a gene also encoding a zinc finger protein, on chromosome 8. Two alternatively spliced variants, encoding the same protein, have been identified.[3]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170631 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ZNF16 zinc finger protein 16".
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dreier B, Segal DJ, Barbas CF (2000). "Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains". J. Mol. Biol. 303 (4): 489–502. doi:10.1006/jmbi.2000.4133. PMID 11054286.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Rousseau-Merck MF, Duro D, Berger R, Thiesen HJ (1995). "Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22". Ann. Genet. 38 (2): 81–4. PMID 7486829.
- Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.