LYN (protéine)

Pour les articles homonymes, voir Lyn.

LYN

Structures disponibles

PDB

Recherche d'orthologue: PDBe RCSB

Identifiants PDB
1W1F, 1WA7, 3A4O

Identifiants

Aliases

LYN

IDs externes

OMIM: 165120 MGI: 96892 HomoloGene: 55649 GeneCards: LYN

Position du gène (Homme)

Chr.	Chromosome 8 humain^[1]

Locus	8q12.1	Début	55,879,835 bp^[1]
Locus	8q12.1	Fin	56,014,169 bp^[1]

Position du gène (Souris)

Chr.	Chromosome 4 (souris)^[2]

Locus	4 A1\|4 2.05 cM	Début	3,678,115 bp^[2]
Locus	4 A1\|4 2.05 cM	Fin	3,813,122 bp^[2]

Expression génétique

Bgee

Humain

Souris (orthologue)

Fortement exprimé dans

monocyte

sang

palpebral conjunctiva

moelle osseuse

nasal epithelium

cellule de la moelle osseuse

appendice iléo-cæcal

ligament alvéolo-dentaire

granulocyte

os spongieux

Fortement exprimé dans

stroma of bone marrow

granulocyte

sang

ganglion mésentérique

Vasculature of brain

rate

tibiofemoral joint

lobe pulmonaire droit

poumon gauche

left lung lobe

Plus de données d'expression de référence

BioGPS

n/a

Gene Ontology
Fonction moléculaire	transmembrane transporter binding SH3 domain binding liaison de complexe macromoléculaire activité kinase gamma-tubulin binding signaling receptor binding liaison ATP protein kinase activity non-membrane spanning protein tyrosine kinase activity liaison enzymatique activité de transférase platelet-derived growth factor receptor binding integrin binding liaison protéique glycosphingolipid binding protein tyrosine kinase activity liaison nucléotide phosphoprotein binding ubiquitin protein ligase binding ephrin receptor binding phosphorylation-dependent protein binding
Composant cellulaire	cytoplasme cytosol membrane extrinsic component of cytoplasmic side of plasma membrane mitochondrial intermembrane space perinuclear region of cytoplasm noyau mitochondrial membranes radeau lipidique exosome appareil de Golgi membrane plasmique postsynaptic density mast cell granule integrin alpha2-beta1 complex Crête mitochondriale intracellular membrane-bounded organelle glutamatergic synapse postsynaptic specialization, intracellular component
Processus biologique	regulation of protein phosphorylation cellular response to extracellular stimulus cellular response to retinoic acid positive regulation of B cell receptor signaling pathway tolerance induction to self antigen regulation of mast cell activation regulation of cell adhesion mediated by integrin cellular response to heat response to amino acid hématopoïèse adaptive immune response regulation of erythrocyte differentiation cellular response to DNA damage stimulus positive regulation of Fc receptor mediated stimulatory signaling pathway platelet activation Fc-epsilon receptor signaling pathway phosphorylation des protéines regulation of B cell apoptotic process positive regulation of dendritic cell apoptotic process positive regulation of glial cell proliferation response to carbohydrate regulation of platelet aggregation negative regulation of cell population proliferation B cell receptor signaling pathway negative regulation of myeloid leukocyte differentiation dendritic cell differentiation Fc receptor mediated inhibitory signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway regulation of B cell receptor signaling pathway stimulatory C-type lectin receptor signaling pathway response to sterol depletion positive regulation of stress-activated protein kinase signaling cascade regulation of cytokine production response to insulin positive regulation of mast cell proliferation negative regulation of MAP kinase activity regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-tyrosine phosphorylation erythrocyte differentiation protein autophosphorylation oligodendrocyte development regulation of mast cell degranulation positive regulation of phosphorylation viral process réponse à une substance toxique negative regulation of protein phosphorylation Fc receptor mediated stimulatory signaling pathway growth hormone receptor signaling pathway via JAK-STAT phosphorylation processus du système immunitaire regulation of release of sequestered calcium ion into cytosol positive regulation of tyrosine phosphorylation of STAT protein B cell homeostasis immune response-regulating cell surface receptor signaling pathway response to axon injury negative regulation of mast cell proliferation regulation of inflammatory response peptidyl-tyrosine autophosphorylation response to hormone regulation of monocyte chemotaxis leukocyte migration lipopolysaccharide-mediated signaling pathway histamine secretion by mast cell intracellular signal transduction response to organic cyclic compound negative regulation of intracellular signal transduction positive regulation of cell migration ephrin receptor signaling pathway negative regulation of toll-like receptor 2 signaling pathway T cell costimulation response to peptide hormone platelet degranulation coagulation sanguine positive regulation of phosphatidylinositol 3-kinase activity positive regulation of oligodendrocyte progenitor proliferation negative regulation of immune response positive regulation of cell population proliferation positive regulation of neuron projection development negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine phosphorylation negative regulation of B cell proliferation negative regulation of toll-like receptor 4 signaling pathway transduction de signal système immunitaire inné neuron projection development central nervous system development réponse inflammatoire positive regulation of protein phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling différenciation cellulaire positive regulation of Ras protein signal transduction positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
Sources:Amigo / QuickGO

Orthologues

Espèces

Homme

Souris

Entrez


4067


17096

Ensembl


ENSG00000254087


ENSMUSG00000042228

UniProt


P07948


P25911

RefSeq (mRNA)


NM_001111097 NM_002350


NM_001111096 NM_010747

RefSeq (protéine)


NP_001104567 NP_002341


NP_001104566 NP_034877

Localisation (UCSC)

Chr 8: 55.88 – 56.01 Mb

Chr 4: 3.68 – 3.81 Mb

Publication PubMed

^[3]

^[4]

Wikidata

Voir/Editer Humain

Voir/Editer Souris

LYN est une protéine de type tyrosine kinase dont le gène est le LYN situé sur le chromosome 8 humain.

En médecine

Une mutation du gène LYN confère une résistance aux anti-œstrogènes des cancers du sein avec récepteurs à l’œstrogène^[5]. D'autres mutations sont associées avec un risque accru de survenue d'un lupus érythémateux disséminé^[6].

Cible thérapeutique

Le dasatinib inhibe l'activité du LYN^[7].

Notes et références

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000254087 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000042228 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Schwarz LJ, Fox EM, Balko JM et al. LYN-activating mutations mediate antiestrogen resistance in estrogen receptor–positive breast cancer, J Clin Invest, 2014;124:5490–5502
↑ Lu R, Vidal GS, Kelly JA et al. Genetic associations of LYN with systemic lupus erythematosus, Genes Immun, 2009;10:397–403
↑ Choi YL, Bocanegra M, Kwon MJ et al. LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer, Cancer Res, 2010;70:2296–2306