NOD1 |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/c/cb/Protein_NOD1_PDB_2b1w.png/250px-Protein_NOD1_PDB_2b1w.png) |
Structure de la protéine NOD1. Basé sur l'identifiant PDB 2b1w. |
Structures disponibles |
---|
PDB | Recherche d'orthologue: PDBe RCSB |
---|
Identifiants PDB |
---|
2B1W, 2DBD, 2NSN, 2NZ7, 4E9M, 4JQW |
|
|
Identifiants |
---|
Aliases | NOD1 |
---|
IDs externes | OMIM: 605980 MGI: 1341839 HomoloGene: 4440 GeneCards: NOD1 |
---|
Position du gène (Homme) |
---|
![Chromosome 7 humain](//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/300px-Ideogram_human_chromosome_7.svg.png) | Chr. | Chromosome 7 humain[1] |
---|
| Locus | 7p14.3 | Début | 30,424,527 bp[1] |
---|
Fin | 30,478,784 bp[1] |
---|
|
Position du gène (Souris) |
---|
![Chromosome 6 (souris)](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/260px-Ideogram_house_mouse_chromosome_6.svg.png) | Chr. | Chromosome 6 (souris)[2] |
---|
| Locus | 6|6 B3 | Début | 54,900,934 bp[2] |
---|
Fin | 54,949,597 bp[2] |
---|
|
Expression génétique |
---|
Bgee | Humain | Souris (orthologue) |
---|
Fortement exprimé dans | - nerf sural
- left ovary
- right lobe of thyroid gland
- right ovary
- gingival epithelium
- upper lobe of left lung
- left lobe of thyroid gland
- apex of heart
- subcutaneous adipose tissue
- rate
|
| Fortement exprimé dans | - ganglion mésentérique
- granulocyte
- subcutaneous adipose tissue
- nerf ischiatique
- poumon droit
- rate
- col de l'utérus
- myocardium of ventricle
- îlot de Langerhans
- stroma of bone marrow
|
| Plus de données d'expression de référence |
|
---|
BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/f/f8/PBB_GE_NOD1_221073_s_at_fs.png/250px-PBB_GE_NOD1_221073_s_at_fs.png) | Plus de données d'expression de référence |
|
---|
|
Gene Ontology |
---|
Fonction moléculaire | - liaison nucléotide
- protein homodimerization activity
- liaison protéique
- peptidoglycan binding
- identical protein binding
- cysteine-type endopeptidase activator activity involved in apoptotic process
- CARD domain binding
- liaison ATP
- liaison de complexe macromoléculaire
| Composant cellulaire | - cytoplasme
- cytosol
- membrane
- membrane plasmique
- basolateral plasma membrane
- apical plasma membrane
| Processus biologique | - regulation of apoptotic process
- réponse de défense
- detection of biotic stimulus
- intracellular signal transduction
- positive regulation of cell death
- processus du système immunitaire
- positive regulation of JNK cascade
- positive regulation of xenophagy
- positive regulation of NIK/NF-kappaB signaling
- cellular response to muramyl dipeptide
- JNK cascade
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of dendritic cell antigen processing and presentation
- positive regulation of nitric-oxide synthase activity
- defense response to bacterium
- positive regulation of NF-kappaB transcription factor activity
- protein complex oligomerization
- detection of bacterium
- positive regulation of interleukin-1 beta production
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of interleukin-6 production
- positive regulation of tumor necrosis factor production
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- réponse inflammatoire
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- nucleotide-binding oligomerization domain containing signaling pathway
- transduction de signal
- positive regulation of stress-activated MAPK cascade
- defense response to Gram-positive bacterium
- apoptose
- système immunitaire inné
- interleukin-1-mediated signaling pathway
| Sources:Amigo / QuickGO |
|
Orthologues |
---|
Espèces | Homme | Souris |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protéine) | | |
---|
Localisation (UCSC) | Chr 7: 30.42 – 30.48 Mb | Chr 6: 54.9 – 54.95 Mb |
---|
Publication PubMed | [3] | [4] |
---|
|
Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
|