NPM1 |
---|
|
Structure de la protéine NPM1. Basé sur l'identifiant PDB 2p1b. |
Structures disponibles |
---|
PDB | Recherche d'orthologue: PDBe RCSB |
---|
Identifiants PDB |
---|
2LLH, 2P1B, 2VXD |
|
|
Identifiants |
---|
Aliases | NPM1, B23, nucléophosmine (nucleolar phosphoprotein B23, numatrin), nucléophosmine |
---|
IDs externes | OMIM: 164040 MGI: 106184 HomoloGene: 81697 GeneCards: NPM1 |
---|
Position du gène (Homme) |
---|
| Chr. | Chromosome 5 humain[1] |
---|
| Locus | 5q35.1 | Début | 171,387,116 bp[1] |
---|
Fin | 171,411,810 bp[1] |
---|
|
Position du gène (Souris) |
---|
| Chr. | Chromosome 11 (souris)[2] |
---|
| Locus | 11|11 A4 | Début | 33,102,287 bp[2] |
---|
Fin | 33,113,206 bp[2] |
---|
|
Expression génétique |
---|
Bgee | Humain | Souris (orthologue) |
---|
Fortement exprimé dans | - tendon calcanéen
- left ovary
- ventricular zone
- right ovary
- endocol
- body of uterus
- éminence ganglionnaire
- body of pancreas
- right uterine tube
- ectocervix
|
| Fortement exprimé dans | - tail of embryo
- Épiblaste
- tubercule génital
- morula
- embryon
- primary oocyte
- zygote
- secondary oocyte
- embryon
- blastocyste
|
| Plus de données d'expression de référence |
|
---|
BioGPS | | Plus de données d'expression de référence |
|
---|
|
Gene Ontology |
---|
Fonction moléculaire | - ribosomal large subunit binding
- protein homodimerization activity
- ribosomal small subunit binding
- unfolded protein binding
- transcription coactivator activity
- protein kinase inhibitor activity
- histone binding
- Tat protein binding
- NF-kappaB binding
- liaison protéique
- liaison ARN
- protein heterodimerization activity
- Fixation d'acide nucléique
- protein kinase binding
- transcription factor binding
- liaison ARNr
- protein N-terminus binding
- liaison de chromatine
| Composant cellulaire | - cytoplasme
- membrane
- focal adhesion
- spindle pole centrosome
- nucléoplasme
- Centre organisateur des microtubules
- nucléole
- cytosquelette
- noyau
- protein-DNA complex
- granular component
- centrosome
- cytosol
- large ribosomal subunit
- small ribosomal subunit
- nuclear speck
- complexe macromoléculaire
- Ribonucléoprotéine
| Processus biologique | - centrosome cycle
- regulation of eIF2 alpha phosphorylation by dsRNA
- positive regulation of cell cycle G2/M phase transition
- negative regulation of centrosome duplication
- regulation of centriole replication
- réponse au stress
- positive regulation of translation
- CENP-A containing chromatin assembly
- régulation positive de la transcription dépendante de l'ADN
- positive regulation of NF-kappaB transcription factor activity
- protein complex oligomerization
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- regulation of endodeoxyribonuclease activity
- regulation of endoribonuclease activity
- ribosome assembly
- intracellular protein transport
- réparation de l'ADN
- transduction de signal
- negative regulation of cell population proliferation
- assemblage du nucléosome
- viral process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- regulation of transcription by RNA polymerase II
- cellular response to UV
- ribosomal large subunit export from nucleus
- ribosomal small subunit export from nucleus
- rRNA export from nucleus
- cell volume homeostasis
- nucleocytoplasmic transport
- protein localization
- positive regulation of cell population proliferation
- posttranscriptional regulation of gene expression
- negative regulation of gene expression
- regulation of centrosome duplication
- positive regulation of centrosome duplication
- croissance cellulaire
- positive regulation of cellular biosynthetic process
- positive regulation of protein ubiquitination
- regulation of protein stability
- ribosomal large subunit biogenesis
- ribosomal small subunit biogenesis
- negative regulation of apoptotic process
- regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of protein kinase activity
- positive regulation of transcription by RNA polymerase II
- negative regulation of mRNA splicing, via spliceosome
- protein stabilization
- protein homooligomerization
- régulation du cycle cellulaire
- positive regulation of protein localization to nucleolus
- Remodelage de la chromatine
- regulation of mRNA stability involved in cellular response to UV
| Sources:Amigo / QuickGO |
|
Orthologues |
---|
Espèces | Homme | Souris |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | NM_001037738 NM_002520 NM_199185 NM_001355006 NM_001355009
|
---|
NM_001355007 NM_001355010 |
| |
---|
NM_001252260 NM_001252261 NM_008722 |
|
---|
RefSeq (protéine) | NP_001032827 NP_002511 NP_954654 NP_001341935 NP_001341938
|
---|
NP_001341936 NP_001341939 |
| |
---|
NP_001239189 NP_001239190 NP_032748 |
|
---|
Localisation (UCSC) | Chr 5: 171.39 – 171.41 Mb | Chr 11: 33.1 – 33.11 Mb |
---|
Publication PubMed | [3] | [4] |
---|
|
Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
|