• negative regulation of neuron apoptotic process • response to ionizing radiation • germ cell development • positive regulation of calcium ion transport into cytosol • glycosphingolipid metabolic process • B cell apoptotic process • response to salt stress • Sertoli cell proliferation • thymocyte apoptotic process • T cell homeostatic proliferation • post-embryonic development • regulation of mitochondrial membrane permeability involved in apoptotic process • negative regulation of protein binding • cellular response to DNA damage stimulus • regulation of mitochondrial membrane permeability involved in programmed necrotic cell death • odontogenesis of dentin-containing tooth • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of IRE1-mediated unfolded protein response • blood vessel remodeling • positive regulation of neuron apoptotic process • apoptotic process involved in blood vessel morphogenesis • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • 精子形成 • apoptotic signaling pathway • 細胞増殖 • mitochondrion morphogenesis • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of cell population proliferation • 有機物への細胞応答 • B cell homeostatic proliferation • limb morphogenesis • release of matrix enzymes from mitochondria • extrinsic apoptotic signaling pathway • 腎臓発生 • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • negative regulation of apoptotic signaling pathway • myeloid cell homeostasis • regulation of neuron apoptotic process • regulation of cysteine-type endopeptidase activity involved in apoptotic process • endoplasmic reticulum calcium ion homeostasis • response to wounding • intrinsic apoptotic signaling pathway by p53 class mediator • 視床下部発生 • viral process • protein homooligomerization • response to gamma radiation • negative regulation of fibroblast proliferation • positive regulation of intrinsic apoptotic signaling pathway • 毒性物質への反応 • B cell negative selection • mitochondrial fusion • neuron apoptotic process • 男性生殖腺発生 • positive regulation of B cell apoptotic process • regulation of protein heterodimerization activity • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • cellular response to UV • sex differentiation • neuron migration • B cell homeostasis • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of apoptotic process involved in mammary gland involution • 神経系発生 • spermatid differentiation • development of secondary sexual characteristics • positive regulation of developmental pigmentation • retina development in camera-type eye • response to axon injury • positive regulation of mitochondrial membrane permeability involved in apoptotic process • 大脳皮質発生 • 卵胞発生 • 受精 • ectopic germ cell programmed cell death • homeostasis of number of cells within a tissue • positive regulation of release of cytochrome c from mitochondria • B cell receptor apoptotic signaling pathway • negative regulation of endoplasmic reticulum calcium ion concentration • regulation of protein homodimerization activity • apoptotic process involved in embryonic digit morphogenesis • leukocyte homeostasis • positive regulation of apoptotic DNA fragmentation • mitochondrial fragmentation involved in apoptotic process • positive regulation of endoplasmic reticulum unfolded protein response • establishment or maintenance of transmembrane electrochemical gradient • homeostasis of number of cells • 膣発生 • post-embryonic camera-type eye morphogenesis • regulation of mammary gland epithelial cell proliferation • retinal cell programmed cell death • regulation of cell cycle • regulation of mitochondrial membrane potential • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • apoptotic mitochondrial changes • protein complex oligomerization • 窒素利用の制御 • negative regulation of peptidyl-serine phosphorylation • positive regulation of apoptotic process • positive regulation of protein oligomerization • extrinsic apoptotic signaling pathway via death domain receptors • release of cytochrome c from mitochondria • アポトーシス • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • intrinsic apoptotic signaling pathway • regulation of apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • transcription initiation from RNA polymerase II promoter • Unfolded Protein Response • negative regulation of mitochondrial membrane potential
BAX(Bcl-2-associated X protein、Bcl-2結合Xタンパク質)は、ヒトではBAX遺伝子によってコードされるタンパク質で、アポトーシスの調節因子である。BCL2L4(Bcl-2-like protein 4)という名称でも知られる。Bcl-2ファミリーのメンバーはヘテロまたはホモ二量体を形成し、さまざまな細胞活性に関与してアポトーシスの促進または抑制を行う調節因子として機能する。このタンパク質はBCL2とヘテロ二量体を形成し、アポトーシス活性化因子として機能する。BAXはミトコンドリアの電位依存性アニオンチャネル(VDAC)と相互作用して開口を増加させ、膜電位の消失とシトクロムcの放出を引き起こすことが報告されている。この遺伝子の発現はがん抑制因子であるp53によって調節されており、p53を介したアポトーシスに関与することが示されている[5]。
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